2015美国胃肠病协会指南：Lynch综合征的诊断与管理

指南解读：美国胃肠病学会新指南强调加强识别Lynch综合征

This document presentsthe official recommendations ofthe American Gastroenterological Association(AGA) Institute on the diagnosis and management of Lynch Syndrome. Lynch Syndrome (previously referred to as Hereditary Non-Polyposis Colorectal Cancer Syndrome, HNPCC)isthe most common heritable colorectal cancersyndrome, accounting for 2-3% of colorectal cancers, and has an estimated prevalence in the general population of 1 in 440. Individuals with Lynch Syndrome have an estimated lifetime cumulative incidence of colorectal cancer up to 80% and endometrial cancer up to 60%, and also have increased risksfor other cancers, including stomach,small intestine, pancreas, biliary tract, ovary, urinary tract, and glioblastoma multiforme. The syndrome is often underdiagnosed. This guideline was developed by the AGA’s Clinical Guidelines Committee and approved by the AGA Institute GoverningBoard. It focuses on identifying cases of Lynch Syndrome and management of risk of colorectal cancer.