AABB血小板输注的临床实践指南
Approximately 2.2 million platelet doses are transfused annually in the United States . A high proportion of these platelet units are transfused prophylactically to reduce the risk for spontaneous bleeding in patients who are thrombocytopenic after chemotherapy or hematopoietic progenitor cell transplantation (HPCT). Unlike other blood components, platelets must be stored at room temperature, limiting the shelf life of platelet units to only 5 days because of the risk for bacterial growth during storage. Therefore, maintaining hospital platelet inventories is logistically difficult and highly resource-intensive. Platelet transfusion is associated with several risks to the recipient, including allergic reactions and febrile nonhemolytic reactions. Sepsis from a bacterially contaminated platelet unit represents the most frequent infectious complication from any blood product today. In any situation where platelet transfusion is being considered, these risks must be balanced against the potential clinical benefits.
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