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抗血小板药物预防先兆子痫:一项对单个患者资料的荟萃分析

Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data
2012-05-08 16:34点击:19次发表评论
作者:Askie LM, for the PARIS Collaborative Group 【View at publisher】 【全球专家评论】
期刊: LANCET NEUROL2012年1月期卷 专家评级: 循证评级:B

Abstract

Background:

Pre-eclampsia is a major cause of mortality and morbidity during pregnancy and childbirth. Antiplatelet agents, especially low-dose aspirin, might prevent or delay pre-eclampsia, and thereby improve outcome. Our aim was to assess the use of antiplatelet agents for the primary prevention of pre-eclampsia, and to explore which women are likely to benefit most.

Methods:

We did a meta-analysis of individual patient data from 32 217 women, and their 32 819 babies, recruited to 31 randomised trials of pre-eclampsia primary prevention.

Findings:

For women assigned to receive antiplatelet agents rather than control, the relative risk of developing pre-eclampsia was 0·90 (95% CI 0·84–0·97), of delivering before 34 weeks was 0·90 (0·83–0·98), and of having a pregnancy with a serious adverse outcome was 0·90 (0·85–0·96). Antiplatelet agents had no significant effect on the risk of death of the fetus or baby, having a small for gestational age infant, or bleeding events for either the women or their babies. No particular subgroup of women was substantially more or less likely to benefit from antiplatelet agents than any other.

Interpretation:

Antiplatelet agents during pregnancy are associated with moderate but consistent reductions in the relative risk of pre-eclampsia, of birth before 34 weeks' gestation, and of having a pregnancy with a serious adverse outcome.

学科代码:妇产科学   关键词:
来源: 国际医学期刊
国际医学期刊介绍:信息来自于Pubmed,包括超过2100万出处生物医学文献来自Medline、生命科学期刊、在线书籍。引用内容链接到全文内容、公共医学中心和出版商的网站。 马上访问国际医学期刊网站http://www.pubmed.com/
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