由胃食管反流导致的闭塞性细支气管炎迁延性肺炎

Bronchiolitis obliterans organizing pneumonia due to gastroesophageal reflux
2015-07-21 07:20发表评论
作者:Liu, J.-R., Xu, X.-F., Zhou, C.-J., Yang, H.-M., Zhao, S.-Y.
机构: 首都医科大学附属北京儿童医院呼吸科
期刊: PEDIATRICS2015年6月6期135卷

The most common causes of bronchiolitis obliterans organizing pneumonia (BOOP) are connective tissue diseases, organ transplantation, drug reaction, and infections. Although rare, BOOP due to gastroesophageal reflux (GER) has been reported in adults but not to date in pediatric patients. This study describes 2 pediatric patients who developed GER and BOOP. One patient had superior mesenteric artery syndrome and Helicobacter pylori infection, and the other had a gastroduodenal ulcer with reflux esophagitis. Respiratory symptoms occurred concurrently or after gastrointestinal symptoms. Monitoring of esophageal pH for 24 hours revealed pathologic acid reflux. Lung biopsy findings confirmed BOOP. No other causes of BOOP were observed in these 2 patients. Both patients were cured with antireflux therapy and corticosteroids. To our knowledge, this is the first case report to implicate GER as a reversible cause of BOOP in children. Copyright © 2015 by the American Academy of Pediatrics.

 

通讯机构:Department of Respiratory Medicine, Beijing Children's Hospital, Capital Medical University, Beijing, China
学科代码:儿科学   关键词:胃食管反流 闭塞性细支气管炎 延性肺炎 ,中国作者重要发表 爱思唯尔医学网, Elseviermed
来源: Scopus
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