结肠癌进展受APEX1介导上调阻值驱动
Introduction
Notch signaling plays an important role in determining cell fate and maintaining progenitor cell populations as well as the balance among cell proliferation, differentiation, and apoptosis (1). Abnormal activation of the Notch signaling pathway has been linked to various developmental disorders and multiple malignancies (2, 3).
The Notch pathway is activated when specific ligands, such as Jagged1 (encoded by JAG1), bind to 4 related transmembrane Notch receptors. Upon ligand binding, Notch proteins are cleaved by the γ-secretase protease complex, releasing the Notch intercellular domain. Cleaved Notch then translocates to the nucleus, where it interacts with the DNA-b
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来源: J Clin Invest.
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