金黄色葡萄球菌LTA诱发的miR-143抑制皮肤中痤疮丙酸杆菌介导的炎性反应

Staphylococcal LTA-Induced miR-143 Inhibits Propionibacterium acnes-Mediated Inflammatory Response in Skin
2016-09-30 07:35点击:130次发表评论
作者:Xia, X., Li, Z., Liu, K., Wu, Y., Jiang, D. , Lai, Y.
机构: 华东师范大学生命科学院;上海市调控生物学重点实验室
期刊: J Invest Dermatol2016年1月3期136卷

Staphylococcus epidermidis (S. epidermidis) plays a critical role in modulating cutaneous inflammatory responses in skin. Although S. epidermidis has been shown to co-colonize with Propionibacterium acnes (P. acnes) in acne lesions, it is unclear whether S. epidermidis is involved in the regulation of P. acnes-induced inflammatory responses. In this study, we demonstrated that S. epidermidis inhibited P. acnes-induced inflammation in skin. P. acnes induced the expression of interleukin-6 and tumor necrosis factor-α via the activation of toll-like receptor (TLR) 2 in both keratinocytes and mouse ears. Staphylococcal lipoteichoic acid activated TLR2 to induce miR-143 in keratinocytes, and miR-143, in turn, directly targeted 3′ UTR of TLR2 to decrease the stability of TLR2 mRNA and then decreased TLR2 protein, thus inhibiting P. acnes-induced proinflammatory cytokines. The inhibitory effect of miR-143 was further confirmed in vivo as the administration of miR-143 antagomir into mouse ears abrogated the inhibitory effect of lipoteichoic acid on P. acnes-induced inflammation in skin. Taken together, these observations demonstrate that staphylococcal lipoteichoic acid inhibits P. acnes-induced inflammation via the induction of miR-143, and suggest that local modulation of inflammatory responses by S. epidermidis at the site of acne vulgaris might be a beneficial therapeutic strategy for management of P. acnes-induced inflammation. © 2015 The Authors

通讯机构:Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, China
学科代码:基础医学 皮肤病学   关键词:金黄色葡萄球菌LTA miR-143 皮肤 痤疮丙酸杆菌 ,中国作者重要发表 爱思唯尔医学网, Elseviermed
来源: Scopus
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