表观基因组范围关联分析检出9个银屑病相关皮肤DNA甲基化位点

Epigenome-Wide Association Analysis Identified Nine Skin DNA Methylation Loci for Psoriasis
2016-09-30 13:34发表评论
作者:Zhou, F., Wang, W., Shen, C., Li, H., Zuo, X., Zheng, X., Yue, M., Zhang, C., Yu, L., Chen, M.abd, Zhu, C., Yin, X., Tang, M., Li, Y., Chen, G., Wang, Z., Liu, S., Zhou, Y., Zhang, F., Zhang, W., Li, C., Yang, S. , Sun, L. , Zhang, X
机构: 安徽医科大学第一附属医院皮肤病研究所暨皮肤科
期刊: J Invest Dermatol2016年1月4期136卷

Psoriasis is a chronic hyperproliferative and inflammatory skin disease caused by the interplay of genetic and environmental factors. DNA methylation has been linked to psoriasis, but the manner in which this process contributes to the disease is not fully understood. In this study, we carried out a three-stage epigenome-wide association study to identify disease-associated differentially methylated sites using a combination of 262 skin and 48 peripheral blood mononuclear cell samples. We not only revealed genome-wide methylation patterns for psoriasis but also identified strong associations between the skin-specific DNA methylation of nine disease-associated differentially methylated sites and psoriasis (Wilcoxon ranked PBonferroni < 0.01; methylation level difference > 0.10). Further analysis revealed that these nine disease-associated differentially methylated sites were not significantly affected by genetic variations, supporting their remarkable contributions to disease status. The expression of CYP2S1, ECE1, EIF2C2, MAN1C1, and DLGAP4 was negatively correlated with DNA methylation. These findings will help us to better understand the molecular mechanism of psoriasis.

© 2015 The Authors

通讯机构: Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China
学科代码:基础医学 皮肤病学   关键词:表观基因 银屑病 皮肤DNA甲基化 ,中国作者重要发表 爱思唯尔医学网, Elseviermed
来源: Scopus
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