急性胰腺炎中生大黄对生长抑素的辅助作用:一项对随机对照试验进行的meta分析

Add-on effect of crude rhubarb to somatostatin for acute pancreatitis: A meta-analysis of randomized controlled trials
2017-02-27 08:10发表评论
作者:Zhou, Y, Wang, L, Huang, X, Li, H, Xiong, Y.
机构: 西南医科大学附属医院胃肠外科
期刊: J Ethnopharmacol2016年12月期194卷

Ethnopharmacological relevance Rhubarb is one of the common herbs used in traditional Chinese complex prescriptions for the treatment of various inflammatory diseases. We sought to determine the add-on effect of crude rhubarb to somatostatin in patients with acute pancreatitis by conducting a meta-analysis. Materials and methods We searched the Pubmed, EMBASE, Cochrane Library, CNKI, Wanfang, VIP databases up to November 2015. Randomized controlled trials (RCTs) comparing crude rhubarb plus somatostatin to somatostatin alone for acute pancreatitis were included. Risk ratio (RR) or weighted mean difference (WMD) with their 95% confidence interval (CI) was calculated between with and without crude rhubarb therapy. Results A total of 19 RCTs involving 1161 patients were identified. Compared with somatostatin alone, crude rhubarb plus somatostatin significantly reduced the total complications (RR 0.55; 95% CI 0.41–0.73) and APACHE Ⅱ scores (WMD −1.16; 95% CI −1.91 to −0.41) as well as shortened the duration of elevated serum amylase (WMD −2.01 days; 95% CI −2.57 to −1.44), duration of abdominal pain (WMD −1.33 days; 95% CI −1.61 to −1.05), the first defecation time (WMD −2.27 days; 95% CI −3.06 to −1.47), and duration of hospital stay (WMD −6.70 days; 95% CI −8.81 to −4.60). However, there were no significant differences in total mortality rates (RR 0.61; 95% CI 0.34 to 1.12) between two groups. Conclusions Crude rhubarb as adjuvant therapy to somatostatin appears to have additional benefits in patients with acute pancreatitis. However, interpretation of these results should be cautioned due to the methodological flaws. © 2016

通讯机构:Department of Gastrointestinal Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
学科代码:内科学 补充和替代医学 药学   关键词:急性胰腺炎 生长抑素的 ,中国作者重要发表 爱思唯尔医学网, Elseviermed
来源: Scopus
Scopus介绍:Scopus 于2004年11月正式推出,是目前全球规模最大的文摘和引文数据库。Scopus涵盖了由5000多家出版商出版发行的科技、医学和社会科学方面的18,000多种期刊,其中同行评审期刊16,500多种。相对于其他单一的文摘索引数据库而言,Scopus的内容更加全面,学科更加广泛,特别是在获取欧洲及亚太地区的文献方面,用户可检索出更多的文献数量。通过Scopus,用户可以检索到1823年以来的近4000万条摘要和题录信息,以及1996年以来所引用的参考文献。数据每日更新。 马上访问Scopus网站http://www.scopus.com/
顶一下(0
您可能感兴趣的文章
发表评论网友评论(0)
发表评论
登录后方可发表评论,点击此处登录