ECCO-ESPGHAN儿童溃疡性结肠炎指南

ECCO-ESPGHAN Paediatric Ulcerative Colitis Guidelines
期刊: J PEDIATR GASTR NUTR2012年9月3期55卷

Background and Aims: Pediatric ulcerative colitis (UC) shares manyfeatures with adult-onset disease but there are some uniqueconsiderations; therefore, therapeutic approaches have to be adapted tothese particular needs. We aimed to formulate guidelines for managingUC in children based on a systematic review (SR) of the literature anda robust consensus process. The present article is a product of a jointeffort of the European Crohn’s and Colitis Organization (ECCO) andthe European Society for Paediatric Gastroenterology, Hepatology, andNutrition (ESPGHAN).

Methods: A group of 27 experts in pediatric IBD participated in aniterative consensus process including 2 face-to-face meetings, followingan open call to ESPGHAN and ECCO members. A list of 23 predefinedquestions were addressed by working subgroups based on a SR of theliterature.

Results: A total of 40 formal recommendations and 68 practice points wereendorsed with a consensus rate of at least 89% regarding initial evaluation,how to monitor disease activity, the role of endoscopic evaluation, medicaland surgical therapy, timing and choice of each medication, the role ofcombined therapy, and when to stop medications. A management flowchart,based on the Pediatric Ulcerative Colitis Activity Index (PUCAI), ispresented.

Conclusions: These guidelines provide clinically useful points to guide themanagement of UC in children. Taken together, the recommendations offera standardized protocol that allows effective, timely management and monitoring of the disease course, while acknowledging that each patient isunique.

主要内容:ECCO和ESPGHAN两个组织对大量文献进行了分析和评估后,对儿童溃疡性结肠炎的内镜检查、药物治疗时机和选择、联合治疗等方面给出了建议和临床实践指导。

学科代码:消化病学   关键词:ECCO-ESPGHAN儿童溃疡性结肠炎指南
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