仅接受手术切除的食管鳞状细胞癌患者的预后因素与结局:对美国联合委员会食管鳞状细胞癌分期系统第7版的评估

Prognostic factors and outcome for patients with esophageal squamous cell carcinoma underwent surgical resection alone: Evaluation of the seventh edition of the American Joint Committee on cancer staging system for esophageal squamous cell carcinoma
作者:Chen, S.-B.a, Weng, H.-R.a, Wang, G.a, Yang, J.-S.
机构: 汕头大学医学院附属肿瘤医院胸外科
期刊: J THORAC ONCOL2013年4月4期8卷

Department of Thoracic Surgery, Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, Guangdong, 515000, China

INTRODUCTION: More data are essential to test the efficacy of the seventh edition of the American Joint Committee on Cancer (AJCC) staging system for esophageal squamous cell carcinoma (ESCC). This retrospective study was designed to identify the prognostic factors for survival of patients with ESCC who underwent surgical resection alone and to evaluate the new AJCC staging system for ESCC. METHODS: Data of a single-center cohort of 2011 patients with ESCC who underwent surgical resection alone according to the new staging system were reviewed. Univariate and multivariate analyses were performed to identify prognostic factors. RESULTS: The 1-, 3-, and 5-year overall survival rates were 83.5, 57.4, and 47.4%, respectively, with a median survival time of 51.0 months. Age, histologic grade, R-category, pT category, pN category, pM category, pTNM stage, and the extent of lymph node metastasis were independent prognostic factors (p < 0.05). In separate subgroup analyses, the survival differences were not significant for pN2 versus pN3 category (p = 0.159) and stages IA versus IB (p = 0.922). Subdivisions by depth of infiltration rather than tumor grade for pT1N0M0 cancers and modified nodal categories (0, 1, 2-3, and ≥4 positive lymph nodes) better represented a survival advantage. CONCLUSIONS: The seventh edition of the AJCC staging system for ESCC is acceptable in predicting survival. However, tumor location does not influence survival in our study. Subdivisions of pT1N0M0 cancers and the N-classification may need to be modified. Copyright © 2013 by the International Association for the Study of Lung.

Chen, Y.-P.; Department of Thoracic Surgery, Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, Guangdong, 515000, China; email:stchenyp@hotmail.com

通讯作者:Chen, Y.-P.; Department of Thoracic Surgery, Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, Guangdong, 515000, China; email:stchenyp@hotmail.com
学科代码:呼吸病学   关键词:Only_accept_surgical_resection
来源: Scopus
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