PDGF-D在肿瘤发生过程中EMT进展中的新兴角色

Emerging roles of PDGF-D in EMT progression during tumorigenesis ( Review )
作者:Wu, Q. , Hou, X. , Xia, J. , Qian, X. , Miele, L.
机构: 蚌埠医学院附属第一医院肿瘤内科
期刊: CANCER TREAT REV2013年10月6期39卷

Department of Medical Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui, China

 

Platelet-derived growth factor-D (PDGF-D) signaling pathway has been reported to be involved in regulating various cellular processes, such as cell growth, apoptotic cell death, migration, invasion, angiogenesis and metastasis. Recently, multiple studies have shown that PDGF-D plays a critical role in governing epithelial-to-mesenchymal transition (EMT), although the underlying mechanism of PDGF-D-mediated acquisition of EMT is largely unclear. Therefore, this mini review will discuss recent advances in our understanding of the role of PDGF-D in the acquisition of EMT during tumorigenesis. Furthermore, we will summarize the function of chemical inhibitors and natural compounds that are known to inactivate PDGF-D signaling pathway, which leads to the reversal of EMT. In summary, inactivation of PDGF-D could be a novel strategy for achieving better treatment outcome of patients inflicted with cancers.

 

 

通讯作者:Wu, Q.; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, MA 02215, United States; email:qiongwu68@yahoo.com.cn
学科代码:肿瘤学   关键词:EMT; Invasion; Migration; MiRN
来源: Scopus
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