原发性高血压患者中的新发糖尿病与心血管事件:一项6年随访研究

New-onset diabetes and cardiovascular events in essential hypertensives: A 6-year follow-up study
作者:" Dimitris Tsiachrisa, Costas Tsioufisa, Co 【View at publisher】 【全球专家评论】
期刊: INT J CARDIOL2011年1月2期153卷 专家评级:★★ 循证评级:A

Background:

Controversy still exists regarding the impact of new-onset diabetes (NOD) on CV outcomes among patients with hypertension. Our aim was to determine the incidence of NOD in essential hypertensives and to evaluate its association with major cardiovascular (CV) events.

Methods:

We followed-up for a mean period of 6years 1572 essential hypertensives (mean age 54.3years, 696 males) for the incidence of NOD, as well as of fatal and non-fatal coronary artery disease and stroke. Based on the development of NOD, the cohort was divided into patients with pre-existing diabetes (10%), patients with NOD (10%) and those who remained free from diabetes.

Results:

During the follow-up period, new or recurrent cases of coronary artery disease and stroke events occurred at a rate of 5.6% (n=88) and 4.65% (n=73). The independent predictors for NOD were age (OR=1.026, p=0.041), waist circumference (OR=1.044, p<0.001), family history of diabetes (OR=2.173, p=0.003) and systolic BP at follow-up (OR 1.022, p=0.044). The presence of NOD was independently associated with greater incidence of stroke (HR 2.404, p=0.046), along with age (HR 1.078, p<0.001), duration of hypertension (HR 1.039, p=0.017) and office systolic blood pressure at follow-up (HR 1.022, p=0.026), whereas development of NOD had no relationship with the incidence of coronary artery disease.

Conclusions:

Our findings indicate the high incidence of NOD and its close association with stroke in essential hypertension. Poorer control of hypertension appears to be a common denominator of both NOD and stroke in this setting.

学科代码:内分泌学与糖尿病   关键词:原发性高血压患者中的新发糖尿病与心血管事件:一项6年随访研究
来源: Eclips
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