雷帕霉素可延长小鼠寿命但限制对衰老的影响
Introduction
Aging is an important risk factor for a number of disorders and functional impairments. Therapeutic targeting of the aging process may therefore represent an innovative strategy in the quest for novel and potentially broadly effective treatments against diseases associated with old age, including neurodegenerative diseases, cardiovascular diseases, cancers, and type 2 diabetes mellitus (1).
The vast majority of current research that aims to identify novel anti-aging interventions uses lifespan measures as a primary readout to detect anti-aging effects. Mechanisms involved in cell growth and metabolism are commonly implicated players in lifespan regulation (2). Specifi
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来源: J Clin Invest.
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