舒尼替尼标准 vs. 调整剂量方案治疗转移性肾细胞癌:来自大型回顾性分析的结果

Standard vs Adapted Sunitinib Regimen in Elderly Patients with Metastatic Renal Cell Cancer: Results from a Large Retrospective Analysis
2013-12-30 11:58点击:958次发表评论
期刊: CLIN GENITOURIN CANC2013年12月期卷

Background

There are no data on the patterns of care and outcome of elderly patients with mRCC treated with sunitinib. In a retrospective study, we assessed the routine use of first-line sunitinib in mRCC patients aged ≥ 70 years.

 

Patients and Methods

We reviewed the clinical files of 185 patients aged >70 years with mRCC treated with first-line sunitinib in seventeen Italian Oncology Units from February 2006 to September 2011. One hundread twenty-three patients (66.5%) received a standard 50 mg/d 4 wk on/2 wk off regimen (SR), and 62 patients (33.5%) received an adapted regimen (AR) consisting in 37.5 mg/d 4 wk on/2 wk off in 67.7% of cases.

 

Results

Median age was 74 years. Patients treated with an AR were older than those treated with the SR (P <.0001). In the overall population, the median progression-free survival (PFS) was 11 months, and the median overall survival (OS) was 25.5 months. Grade 3-4 toxicities occurred in 70.7% of SR and 51.6% of AR, respectively; dose reductions were required in 66.7% and 41.9%, respectively; discontinuations due to therapy-related adverse events occurred in 20.3% and 24.2%, respectively. In multivariate analysis, only performance status and the Heng score were predictors of either PFS or OS.

 

Conclusions

Sunitinib is active and feasible in elderly patients with mRCC. A sunitinib AR could be considered as an option in selected older mRCC patients. The optimal treatment of frail patients with mRCC remains to be established.

 

主要结论:对于老年转移性肾细胞患者,舒尼替尼治疗可行,有效。调整剂量方案可被用于经选择的老年转移性肾细胞癌患者中。

学科代码:肿瘤学 泌尿外科学   关键词:Standard; adapted sunitinib re ,全球精选文摘 爱思唯尔医学网, Elseviermed
来源: 爱思唯尔
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