端粒酶逆转录基因启动子突变有助于识别泌尿生殖肿瘤的起源:一项遗传与分子研究

Telomerase reverse transcriptase gene promoter mutations help discern the origin of urogenital tumors: A genomic and molecular study
作者:Wu, S. | Huang, P. | Li, C. | Huang, Y. | Li, X. | Wang, Y. | Chen, C. | Lv, Z. | Tang, A. | Sun, X. | Lu, J. | Li, W. | Zhou, J. | Gui, Y. | Zhou, F. | Wang, D. | Cai, Z.
机构: 深圳大学第一附属医院 深圳市第二人民医院
期刊: EUR UROL2014年2月2期65卷

Abstract

Activation of telomerase can be observed in almost all human tumor histotypes and detection of the urinary telomerase activities is useful for the diagnosis and surveillance of bladder cancer. In this study, we screened, by Sanger sequencing, 302 patients with various urogenital cancers for somatic mutations in the promoter of the telomerase reverse transcriptase (TERT) gene and determined the clinical relevance of TERT promotermutations in urogenital cancer. In vitro assays were also performed to evaluate the functional influence of the discovered mutations. We found that the frequencies of somatic mutations in the TERT promoter varied substantially between different types of urogenital tumors (range: 0-63.7%), with urothelial carcinomas showing the highest mutation frequency and prostate cancer showing no mutation. The mutations upregulated the expression of TERT and enhanced the invasiveness of the tumor cells. The mutations were more prevalent in older patients with invasive diseases and advanced tumor stages, and were associated with significantly shorter survival time. Moreover, we also observed a significant co-occurrence of mutationsbetween the TERT promoter and the tumor protein 51/retinoblastoma1 (TP53/RB1) signaling pathway. Hence, TERT promoter mutations may serve as important markers for the differential diagnosis and surveillance of urogenital tumors.

通讯作者:Shenzhen Second People's Hospital, First Affiliated Hospital, Shenzhen University, Shenzhen, China
学科代码:肾脏病学 泌尿外科学   关键词:端粒酶逆转
来源: Scopus
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