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通过定位于跨膜蛋白在体内对胰腺β细胞进行多模态成像

Multimodal imaging of pancreatic beta cells in vivo by targeting transmembrane protein
2012-07-16 12:25点击:4次发表评论
作者:D. Vats, H. Wang, D. Esterhazy,
期刊: DIABETOLOGIA2012年8月8期55卷

Abstract
Aims/hypothesis  
Non-invasive diagnostic tools specific for pancreatic beta cells will have a profound impact on our understanding of the pathophysiology of metabolic diseases such as diabetes. The objective of this study was to use molecular imaging probes specifically targeting beta cells on human samples and animal models using state-of-the-art imaging modalities (fluorescence and PET) with preclinical and clinical perspective.
Methods  
We generated a monoclonal antibody, 8/9-mAb, targeting transmembrane protein 27 (TMEM27; a surface N-glycoprotein that is highly expressed on beta cells), compared its expression in human and mouse pancreas, and demonstrated beta cell-specific bindi

学科代码:内科学   关键词:Beta cells Diabetes hTMEM27 Imaging Insulinomas Near infrared frequency
来源: DIABETOLOGIA
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