多囊卵巢综合征女性患者的高雄激素血症和高胰岛素血症在妊娠期间得到改善：其女儿的卵巢滤泡重量的潜在影响

Objective:

To evaluate the ovarian function during early infancy in daughters of women with polycystic ovary syndrome (PCOS) treated with metformin throughout pregnancy (PCOSd+M), as a means to reduce androgen and insulin levels, compared with daughters of nontreated PCOS women (PCOSd−M) and daughters of women who belong to a healthy comparison group (HCd).

Design:

Descriptive and analytic study.

Setting:

Unit of endocrinology and reproductive medicine.

Patient(s):

Fifteen PCOSd+M, 23 PCOSd−M, and 35 HCd were studied at 2–3months of age.

Intervention(s):

A GnRH analogue test was performed with determinations of gonadotropins, sex steroids, SHBG, and anti-Müllerian hormone (AMH).

Main Outcome Measure(s):

Differences in AMH levels between PCOSd+M, PCOSd−M and HCd.

Result(s):

AMH and peak E2 concentrations were significantly higher in PCOSd−M compared with HCd, whereas PCOSd+M exhibited AMH concentrations and peak E2 levels similar to those observed in HCd.

Conclusion(s):

The improvement of the altered endocrine-metabolic environment of PCOS mothers reduces AMH levels in their daughters, which might reflect a decrease in their follicular mass (Fig 1).
Figure 1 Figure 1: Antimüllerian hormone serum concentrations in daughters of PCOS women treated with metformin (PCOSd+M; triangles), of nontreated PCOS women (PCOSd−M; circles) and of women who belong to a healthy comparison group (HCd; squares). *Adjusted P value <.0125 (Bonferroni principle). (Reprinted from Crisosto N, Echiburú B, Maliqueo M, et al, Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular mass of their daughters. Fertil Steril. 2012;97:218-224, Copyright 2012, with permission from American Society for Reproductive Medicine.)