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《疫苗》杂志是爱德华·詹纳学会、国际疫苗学会和日本疫苗学会的官方刊物。主要接受以下方面的投稿：人用疫苗-感染性疾病，人用疫苗-非感染性疾病，兽用疫苗，免疫学与动物模型，载体、佐剂和投药系统，生产与制造，疫苗安全性，监管、社会及法规事项，疫苗学历史。

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Published 2012年10月,Volume 30,Issue 47

最新一期


Page CO2
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Editorial
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Nanovaccinology: The next generation of vaccines meets 21st century materials science and engineering


Pages 6609-6611
Tewodros Mamo, Gregory A. Poland
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Meeting report
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Report of the 5th meeting on influenza vaccines that induce broad spectrum and long-lasting immune responses, World Health Organization, Geneva, 16–17 November 2011


Pages 6612-6622
Bethan Hughes, Frederick Hayden, Yuri Perikov, Joachim Hombach, John S. Tam
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Brief reports
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Efficacy of yeast-derived recombinant hepatitis B vaccine after being used for 12 years in highly endemic areas in China


Pages 6623-6627
Liping Shen, Fuzhen Wang, Feng Wang, Fuqiang Cui, Shuang Zhang, Hui Zheng, Yong Zhang, Xiaofeng Liang, Shengli Bi
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HLA-DR specific monoclonal antibodies block lymphoproliferative response to measles vaccine in vitro: A pilot study


Pages 6628-6631
David M. Phelan, Gregory A. Poland
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Regular papers
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Estimated size of the population at risk of severe adverse events after smallpox vaccination in Israel

 Original Research Article
Pages 6632-6635
Yael Levy, Emilia Anis, Ehud Kaliner, Itamar Grotto, Yehuda L. Danon
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Highlights

► The bioterror threat has prompted formulation of national preparedness strategies. ► We estimated the population at risk of adverse events of smallpox vaccine in Israel. ► The databases of the Israel Ministry of Health and the largest HMO were searched. ► This special population accounted for 4.3% of the national population. ► This information is essential for effective mass-vaccination programs.
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Safety of Zostavax™—A cohort study in a managed care organization

 Original Research Article
Pages 6636-6641
Roger Baxter, Trung Nam Tran, John Hansen, Michael Emery, Bruce Fireman, Joan Bartlett, Ned Lewis, Patricia Saddier
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Highlights

► This was an analysis of safety of the zoster vaccine. ► Risk-interval cohort study. ► 29,000 persons who received the zoster vaccine in 2006 and 2007. ► No clear increase in events was observed in the risk period after vaccination compared to later. ► People received zoster vaccine when their health was optimal, which led to confounding.
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A virus-like particle vaccine for coxsackievirus A16 potently elicits neutralizing antibodies that protect mice against lethal challenge

 Original Research Article
Pages 6642-6648
Qingwei Liu, Kexia Yan, Yanfang Feng, Xulin Huang, Zhiqiang Ku, Yicun Cai, Fei Liu, Jinping Shi, Zhong Huang
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Highlights

► Virus-like particle (VLP) of coxsackievirus A16 was successfully produced. ► VLP immunization potently elicited neutralizing antibodies in mice. ► Passive transfer of anti-VLP sera protected mice against CVA16 lethal infection.
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Effect of the vaccination scheme on PregSure®BVD induced alloreactivity and the incidence ofBovine Neonatal Pancytopenia

 Original Research Article
Pages 6649-6655
Rahel Kasonta, Carola Sauter-Louis, Mark Holsteg, Karin Duchow, Klaus Cussler, Max Bastian
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► Regional differences in the incidence of Bovine Neonatal Pancytopenia (BNP) are identified. ► The differences correlate with variations in the BVD-vaccination regimen. ► The causal correlation is confirmed by experimental immunization.
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Phase II, dose ranging study of the safety and immunogenicity of single dose West Nile vaccine in healthy adults ≥50 years of age

 Original Research Article
Pages 6656-6664
Gustavo H. Dayan, Joan Bevilacqua, Dorothy Coleman, Aileen Buldo, George Risi
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Highlights

► ChimeriVax-WN02 is a live attenuated vaccine for protection against West Nile virus. ► We assessed the immunogenicity and safety of ChimeriVax-WN02 in subjects aged ≥50. ► Subjects were randomized in 3 groups to receive 1 dose of a different formulation. ► Seroconversion was achieved at day 28 by >92% of subjects in each of the groups. ► ChimeriVax-WN02 was well tolerated in subjects in all groups.
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Probing the protective effects of a conformationally constrained nicotine vaccine

Original Research Article
Pages 6665-6670
Amira Y. Moreno, Marc R. Azar, George F. Koob, Kim D. Janda
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Highlights

► Constrained and unconstrained nicotine haptens generate differential immune responses. ► Vaccination of constrained hapten CNI with ALUM showed protective effects in rats. ► High antibody concentration was found to be crucial in conferring protective effects. ► Nicotine analgesia is a rapid assay to probe vaccination effects.
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Efficacy of a reformulated inactivated chimeric PCV1-2 vaccine based on clinical, virological, pathological and immunological examination under field conditions

 Original Research Article
Pages 6671-6677
Hwi Won Seo, Kiwon Han, Yeonsu Oh, Changhoon Park, Chanhee Chae
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Highlights

► Chimeric PCV1-2 vaccine seems to be very effective in controlling PCV2 infection. ► Vaccinated animals displayed an improved ADG and a reduced time to market. ► Vaccination induced strong neutralizing antibodies and PCV2-specific IFN-r-SC. ► Vaccination can elicit PCV2-specific NA and IFN-γ-SC even in the presence of MDA.
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Protective immunity against tick infestation in cattle vaccinated with recombinant trypsin inhibitor of Rhipicephalus microplus

 Original Research Article
Pages 6678-6685
Renato Andreotti, Rodrigo Casquero Cunha, Mariana Aparecida Soares, Felix D. Guerrero, Fábio P. Leivas Leite, Adalberto A. Pérez de León
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Highlights

► Tested vaccine with recombinant Kunitz protein for cattle tick immunoprotection. ► Larval R. microplus trypsin inhibitor was produced in yeast expression system. ► Immunization afforded 32% efficacy against cattle tick infestation. ► Larval R. microplustrypsin inhibitor resembles three-headed Kunitz protein BmTI-6.
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Seroprevalence of seven high-risk HPV types in The Netherlands

 Original Research Article
Pages 6686-6693
Mirte Scherpenisse, Madelief Mollers, Rutger M. Schepp, Hein J. Boot, Hester E. de Melker, Chris J.L.M. Meijer, Guy A.M. Berbers, Fiona R.M. van der Klis
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Highlights

► Pre-HPV vaccine antibody levels serve as baseline to evaluate long-term HPV vaccination effects. ► The increase in HPV seroprevalence in adolescents correlates with sexual debut, mainly for HPV16 in women. ► 10% of the population was found seropositive for multiple HPV serotypes. ► Ethnicity, marital status, casual partnership or having a STD increased the risk of HPV seropositivity.
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No effect of oral polio vaccine administered at birth on mortality and immune response to BCG. A natural experiment

 Original Research Article
Pages 6694-6699
Najaaraq Lund, Andreas Andersen, Ivan Monteiro, Peter Aaby, Christine Stabell Benn
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Highlights

► This study did not support that OPV0 is associated with increased mortality in boys. ► If anything, mortality tended to be higher in infants who did not receive OPV0. ► OPV administered with BCG may lead to a dampened immune response to BCG.
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Distinguishing vaccine efficacy and effectiveness

 Original Research Article
Pages 6700-6705
Eunha Shim, Alison P. Galvani
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Highlights

► There are two mechanisms of vaccine action, ‘all-or-nothing’ and ‘leaky’ vaccines. ► Typical estimation of ‘leaky’ vaccine efficacy has been incorrect in mathematical models. ► We demonstrate how the common measures of vaccine can be correctly estimated.
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Effects of immunization with natural and recombinant lysine decarboxylase on canine gingivitis development

 Original Research Article
Pages 6706-6712
Jennifer L. Peters, Paul L. DeMars, Lindsay M. Collins, Julie A. Stoner, Hiroyuki Matsumoto, Naoka Komori, Anil Singh, Christa L. Feasley, James A. Haddock, Martin Levine
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► Lysine is required to maintain an epithelial barrier to bacteria in gingival sulci. ► Lysine decarboxylase from Eikenella corrodensdepletes lysine from gingival sulci. ► Antibodies to lysine decarboxylase slow lysine depletion and gingivitis progression. ► Lysine decarboxylase vaccination may retard canine periodontal disease progression.
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US Military contributions to the global response to pandemic chikungunya

 Original Research Article
Pages 6713-6720
Charles H. Hoke Jr., Judy Pace-Templeton, Phillip Pittman, Frank J. Malinoski, Paul Gibbs, Tracy Ulderich, Michelle Mathers, Beverly Fogtman, Pamela Glass, David W. Vaughn
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Waning population immunity to measles in Taiwan

 Original Research Article
Pages 6721-6727
Chih-Jung Chen, Ping-Ing Lee, Yu-Chia Hsieh, Po-Yen Chen, Yu-Huai Ho, Chee-Jen Chang, Ding-Ping Liu, Feng-Yee Chang, Cheng-Hsun Chiu, Yhu-Chering Huang, Chin-Yun Lee, Tzou-Yien Lin
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Highlights

► The coverage rate of measles vaccine was >95% for more than a decade in Taiwan. ► We estimated the seroprevalence of measles in Taiwan using volunteer-based samples. ► There was a significant declining trend of seropositivity with age in vaccinees. ► The overall seroprevalence of measles was not sufficient for herd immunity. ► Waning vaccine-induced immunity weakened the population immunity to measles.
Book review
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H. Bazin, ,Vaccination: A History. From Lady Montagu to Genetic Engineering (2011) John Libbey Eurotext,UK.


Page 6728
Andrew W. Artenstein
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