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American Journal of Transplantation
(AM J TRANSPLANT) 《美国移植学杂志》

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该杂志以论坛的形式来辩论和重新评估,是这个充满活力的领域增进了解,改善结果,推进科学进步的主要的新平台。《美国移植学杂志》每月出版,为世界各地的临床医生和研究人员提供了了重要的资源。

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Published 2013年1月,Volume 13,Issue 1

最新一期

  1. The AJT Report

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      The AJT Report: News and issues that affect organ and tissue transplantation(pages 1–2)

      Article first published online: 26 DEC 2012 | DOI: 10.1111/ajt.12071

      Due to privacy restrictions, the SRTR no longer has access to Social Security death data. We take a look at what this means for transplantation research and patient care, and at possible solutions. Also this month, we recount some of the papers written by 2012 Nobel laureate Alvin E. Roth published in the pages of AJT.

  2. Literature Watch

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      LITERATURE Watch: Implications for transplantation (page 3)

      Leonardo Riella and Jonathan S. Bromberg

      Article first published online: 26 DEC 2012 | DOI: 10.1111/ajt.12072

      One of the greatest challenges of modern science is integrating all of the knowledge derived from the identification of innumerable genes, molecules, and cells for the improvement of health; three recent papers suggest the growing field of systems biology might help translate these discoveries into tangible clinical benefits.

  3. Special Feature

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      Dr. Joseph E. Murray (1919–2012): A Life of Curiosity, Humanism, and Persistence(pages 5–6)

      S. G. Tullius

      Article first published online: 26 DEC 2012 | DOI: 10.1111/ajt.12076

      This special tribute commemorates the father of clinical organ transplantation.

  4. Editorials

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      Balancing Accountable Care With Risk Aversion: Transplantation as a Model (pages 7–8)

      D. A. Axelrod

      Article first published online: 26 DEC 2012 | DOI: 10.1111/j.1600-6143.2012.04346.x

      Transplantation is widely regarded as a model of accountability and transparency in healthcare; however, failure to accurately measure and report appropriate performance metrics is likely to result in risk aversion and decreased access to transplant for higher risk populations. See also Schold et al (page 67) and Schnier et al (page 31).

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      The Cam-Path Forward (pages 9–10)

      A. D. Kirk

      Article first published online: 21 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04324.x

      The author discusses the drug alemtuzumab as a case study in the benefits and drawbacks of off-label drug use in organ transplantation. See article by van den Hoogen et al on page 192.

  5. Minireviews

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      MicroRNAs as Biomarkers in Solid Organ Transplantation (pages 11–19)

      V. R. Mas, C. I. Dumur, M. J. Scian, R. C. Gehrau and D. G. Maluf

      Article first published online: 8 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04313.x

      The authors summarize recent reports detailing the identification, mechanism, clinical application and limitations of miRNAs as biomarkers in organ quality, ischemia-reperfusion injury, acute rejection, tolerance and chronic allograft dysfunction.

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      Disruptions in the Supply of Medications Used in Transplantation: Implications and Management Strategies for the Transplant Clinician (pages 20–30)

      J. C. Krisl, C. R. Fortier and D. J. Taber

      Article first published online: 5 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04308.x

      This review discusses the incidence and impact of drug shortages in solid organ transplantation and provides recommendations for transplant clinicians on appropriate therapeutic and global management of these shortages.

  6. Personal Viewpoint

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      Transplantation at the Nexus of Behavioral Economics and Health Care Delivery(pages 31–35)

      K. E. Schnier, J. C. Cox, C. McIntyre, R. Ruhil, V. Sadiraj and N. Turgeon

      Article first published online: 26 DEC 2012 | DOI: 10.1111/j.1600-6143.2012.04343.x

      This viewpoint discusses behavioral economic principles and how they might be applied to transplantation using a synergistic collaboration between transplant physicians and economists. See also editorial by Axelrod on page 7 and article by Schold et al on page 67.

  7. Original Articles

    1. Basic Science

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      Leptin Modulates Allograft Survival by Favoring a Th2 and a Regulatory Immune Profile (pages 36–44)

      P. M. M. Moraes-Vieira, E. J. Bassi, R. A. Larocca, A. Castoldi, M. Burghos, A. P. Lepique, F. J. Quintana, R. C. Araujo, A. S. Basso, T. B. Strom and N. O. S. Câmara

      Article first published online: 27 SEP 2012 | DOI: 10.1111/j.1600-6143.2012.04283.x

      The authors suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection.

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      Cord Blood T Cells Retain Early Differentiation Phenotype Suitable for Immunotherapy After TCR Gene Transfer to Confer EBV Specificity (pages 45–55)

      G. Frumento, Y. Zheng, G. Aubert, M. Raeiszadeh, P. M. Lansdorp, P. Moss, S. P. Lee and F. E. Chen

      Article first published online: 27 SEP 2012 | DOI: 10.1111/j.1600-6143.2012.04286.x

      Human umbilical cord blood T cells can be redirected by T cell receptor gene transduction to target Epstein–Barr virus epitopes, and when compared in vitro with adult T cells they demonstrate properties predictive of better in vivo proliferative capacity and effector function, suggesting that cord blood can be used as a third party source of T cells for immunotherapy of posttransplant lymphoproliferative disease.

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      Targeting TIM-1 on CD4 T Cells Depresses Macrophage Activation and Overcomes Ischemia-Reperfusion Injury in Mouse Orthotopic Liver Transplantation (pages 56–66)

      Y. Zhang, H. Ji, X. Shen, J. Cai, F. Gao, K. M. Koenig, C. M. Batikian, R. W. Busuttil and J. W. Kupiec-Weglinski

      Article first published online: 8 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04316.x

      A subpopulation of activated CD4 T cells expressing the TIM-1 receptor is required to trigger hepatic damage in mouse liver transplants subjected to prolonged periods of cold storage.

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    4. Clinical Science

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      The Association of Center Performance Evaluations and Kidney Transplant Volume in the United States (pages 67–75)

      J. D. Schold, L. D. Buccini, T. R. Srinivas, R. T. Srinivas, E. D. Poggio, S. M. Flechner, C. Soria, D. L. Segev, J. Fung and D. A. Goldfarb

      Article first published online: 26 DEC 2012 | DOI: 10.1111/j.1600-6143.2012.04345.x

      There is a significant association between low performance evaluations of transplant centers in programspecific reports and a decline in kidney transplant volume. See also editorial by Axelrod on page 7 and personal viewpoint by Schnier et al on page 31.

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      Five-Year Outcomes in Living Donor Kidney Transplants With a Positive Crossmatch (pages 76–85)

      A. Bentall, L. D. Cornell, J. M. Gloor, W. D. Park, M. J. Gandhi, J. L. Winters, M. F. Chedid, P. G. Dean and M. D. Stegall

      Article first published online: 16 OCT 2012 | DOI: 10.1111/j.1600-6143.2012.04291.x

      This study demonstrates that patients with anti-class II donor-specific antibodies at baseline in positive crossmatch kidney transplants have increased early transplant glomerulopathy at one year and higher rates of graft loss compared to anti-class I antibodies alone.

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      Chronic Histological Damage in Early Indication Biopsies Is an Independent Risk Factor for Late Renal Allograft Failure (pages 86–99)

      M. Naesens, D. R. J. Kuypers, K. De Vusser, Y. Vanrenterghem, P. Evenepoel, K. Claes, B. Bammens, B. Meijers and E. Lerut

      Article first published online: 8 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04304.x

      In this single-center study, the authors demonstrate that early chronic histological damage in renal allograft indication biopsies is an independent risk factor for late graft loss, irrespective of whether a specific, progressive disease is present.

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      Inhibitors of mTOR and Risks of Allograft Failure and Mortality in Kidney Transplantation (pages 100–110)

      T. Isakova, H. Xie, S. Messinger, F. Cortazar, J. J. Scialla, G. Guerra, G. Contreras, D. Roth, G. W. Burke III, M. Z. Molnar, I. Mucsi and M. Wolf

      Article first published online: 1 OCT 2012 | DOI: 10.1111/j.1600-6143.2012.04281.x

      The authors conduct an observational study of 139,370 recipients who underwent kidney transplantation between 1999 and 2010 in the United States and find that compared with calcineurin-inhibitor-based regimens, use of mammalian target of rapamycin–based regimens for primary immunosuppression is associated with inferior recipient survivals.

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      Medical Outcomes in African American Live Kidney Donors: A Matched Cohort Study (pages 111–118)

      M. D. Doshi, M. O. Goggins, L. Li and A. X. Garg

      Article first published online: 24 OCT 2012 | DOI: 10.1111/j.1600-6143.2012.04303.x

      Live kidney donation is associated with increased incidence of hypertension in African Americans.

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      A Surveillance Model for Skin Cancer in Organ Transplant Recipients: A 22-Year Prospective Study in an Ethnically Diverse Population (pages 119–129)

      C. A. Harwood, D. Mesher, J. M. McGregor, L. Mitchell, M. Leedham-Green, M. Raftery, R. Cerio, I. M. Leigh, P. Sasieni and C. M. Proby

      Article first published online: 16 OCT 2012 | DOI: 10.1111/j.1600-6143.2012.04292.x

      The authors employ an evidence-based approach to skin cancer surveillance in renal transplant recipients in a singlecentre prospective study.

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      Value of Routine Voiding Cystourethrography After Renal Transplantation (pages 130–135)

      M. Margreiter, G. P. Györi, G. A. Böhmig, S. Trubel, F. Mühlbacher and R. Steininger

      Article first published online: 27 SEP 2012 | DOI: 10.1111/j.1600-6143.2012.04284.x

      By examining the value of routine voiding cystourethrography in a large cohort of kidney transplant patients, the authors show that the early vesicoureteral reflux has no meaningful effect on death-censored graft survival or overall patient survival.

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      Polyomavirus BK Replication in De Novo Kidney Transplant Patients Receiving Tacrolimus or Cyclosporine: A Prospective, Randomized, Multicenter Study (pages 136–145)

      H. H. Hirsch, F. Vincenti, S. Friman, M. Tuncer, F. Citterio, A. Wiecek, E. H. Scheuermann, M. Klinger, G. Russ, M. D. Pescovitz and H. Prestele

      Article first published online: 8 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04320.x

      In a study of kidney transplant recipients randomized 1:1 to receive either cyclosporine-A or tacrolimus together with a common backbone of basiliximab induction, mycophenolate and steroids, higher steroid exposure, tacrolimus, male gender and older age are identified as independent risk factors for BK virus in the first year posttransplant. See a related manuscript by Theodoropoulos et al on page 197.

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      High-Quality CMV-Specific CD4+ Memory Is Enriched in the Lung Allograft and Is Associated With Mucosal Viral Control (pages 146–156)

      J. A. Akulian, M. R. Pipeling, E. R. John, J. B. Orens, N. Lechtzin and J. F. McDyer

      Article first published online: 27 SEP 2012 | DOI: 10.1111/j.1600-6143.2012.04282.x

      This study shows that cytomegalovirus-specific CD4+ memory T cells are enriched in the lung allograft, multifunctional, and associated with mucosal viral control in lung transplant recipients.

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      Functional Status After Lung Transplantation in Older Adults in the Post-Allocation Score Era (pages 157–166)

      L. Genao, H. E. Whitson, D. Zaas, L. L. Sanders and K. E. Schmader

      Article first published online: 21 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04299.x

      Lung transplantation has a positive effect on the functional status trajectories of both older (age 65 and higher) and younger (age 18–64) recipients, who rarely reach significant disability at 48 months posttransplantation.

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      Transmission of Angiosarcomas From a Common Multiorgan Donor to Four Transplant Recipients (pages 167–173)

      J. Thoning, Y. Liu, C. Bistrup, A. Thomassen, C. Borst, N. Marcussen and M. Tepel

      Article first published online: 24 OCT 2012 | DOI: 10.1111/j.1600-6143.2012.04301.x

      The authors describe an association of urokinase-plasminogen-activator-receptor in donor tumor transmission of metastatic angiosarcomas to four transplant recipients who received organs from an apparently unaffected, common, deceased multiorgan donor.

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      Comparison of De Novo Cancer Incidence in Australian Liver, Heart and Lung Transplant Recipients (pages 174–183)

      R. Na, A. E. Grulich, N. S. Meagher, G. W. McCaughan, A. M. Keogh and C. M. Vajdic

      Article first published online: 24 OCT 2012 | DOI: 10.1111/j.1600-6143.2012.04302.x

      Cancer incidence is increased in Australian pediatric and adult liver and cardiothoracic transplant recipients, and the risk of cancer is higher in heart and lung recipients as compared to liver transplant recipients.

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      Liver Transplantation Outcome in Patients With Angiographically Proven Coronary Artery Disease: A Multi-Institutional Study (pages 184–191)

      C. Wray, J. C. Scovotti, J. Tobis, C. U. Niemann, R. Planinsic, A. Walia, J. Findlay, G. Wagener, J. B. Cywinski, D. Markovic, C. Hughes, A. Humar, A. Olmos, R. Sierra, R. Busuttil and R. H. Steadman

      Article first published online: 5 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04293.x

      The authors find no significant difference in post-liver transplant survival between patients with and without angiographically proven obstructive coronary artery disease when current treatment regimens are employed.

  8. Brief Communications

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      Treatment of Steroid-Resistant Acute Renal Allograft Rejection With Alemtuzumab(pages 192–196)

      M. W. F. van den Hoogen, D. A. Hesselink, W. J. van Son, W. Weimar and L. B. Hilbrands

      Article first published online: 21 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04328.x

      The authors show that alemtuzumab might be equally effective and as safe as antithymocyte globulin for the treatment of steroid-resistant renal allograft rejections, but with a significantly lower incidence of infusion-related side effects, the possibility to administer alemtuzumab subcutaneously, and lower costs. See editorial by Kirk on page 9.

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      BK Virus Replication and Nephropathy After Alemtuzumab-Induced Kidney Transplantation (pages 197–206)

      N. Theodoropoulos, E. Wang, S. Penugonda, D. P. Ladner, V. Stosor, J. Leventhal, J. Friedewald, M. P. Angarone and M. G. Ison

      Article first published online: 8 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04314.x

      This retrospective cohort study of 666 kidney transplant recipients shows that the incidence of BK viruria, viremia and nephropathy is not significantly different among kidney transplant recipients who receive alemtuzumab induction when compared to patients who receive less potent induction. See article by Hirsch et al on page 136.

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      Human Herpesvirus 8 (HHV8) Transmission and Related Morbidity in Organ Recipients (pages 207–213)

      C. Lebbe, R. Porcher, A. G. Marcelin, F. Agbalika, E. Dussaix, D. Samuel, S. Varnous, S. Euvrard, A. Bigorie, H. Creusvaux, C. Legendre and C. Frances, the Skin and Organ Transplantation Group of the French Society of Dermatology

      Article first published online: 11 OCT 2012 | DOI: 10.1111/j.1600-6143.2012.04290.x

      This prospective French national cohort study shows a cumulative incidence of 28% of human herpesvirus-8 seroconversion among organ transplant recipients at risk of contamination, without any difference regardless of the organ transplanted, together with an overall very low prevalence of positive viremia and morbidity.

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      Incidence of Primary and Second Cancers in Renal Transplant Recipients: A Multicenter Cohort Study (pages 214–221)

      G. Tessari, L. Naldi, L. Boschiero, E. Minetti, S. Sandrini, F. Nacchia, F. Valerio, C. Rugiu, F. Sassi, E. Gotti, L. Fonte, G. Talamini and G. Girolomoni

      Article first published online: 11 OCT 2012 | DOI: 10.1111/j.1600-6143.2012.04294.x

      Renal transplant recipients are at high risk of primary and second cancers, including unusual cancers, but cancer-related mortality is not substantially increased if compared to an age- and sex-matched reference population.

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      A Novel Organ Preservation for Small Partial Liver Transplantations in Rats: Venous Systemic Oxygen Persufflation With Nitric Oxide Gas (pages 222–228)

      S. Yagi, K. Nagai, P. Kadaba, M. Afify, S. Teramukai, S. Uemoto and R. H. Tolba

      Article first published online: 5 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04310.x

      The authors report that venous systemic oxygen persufflation with nitric oxide gas is a novel, effective method for small partial liver transplantation in rats that alleviates liver graft injury and improves regeneration.

  9. Case Report

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      Triple Red Blood Cell Alloantibody Formation After Bone-Allograft Transplantation(pages 229–231)

      L. Prinzen, H. M. Staal, S. J. M. Rouwette, E. A. M. Beckers, R. H. M. ten Broeke, L. W. van Rhijn and Y. M. C. Henskens

      Article first published online: 24 OCT 2012 | DOI: 10.1111/j.1600-6143.2012.04300.x

      A 13-year-old boy with no history of blood transfusions developed three different rhesus alloantibodies after receiving a bone allograft, providing evidence that primary red blood cell immunization is possible after bone allograft transplantation.

  10. Reports From the CDC: MMWR

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      Use of 13-Valent Pneumococcal Conjugate Vaccine and 23-Valent Pneumococcal Polysaccharide Vaccine for Adults With Immunocompromising Conditions: Recommendations of the Advisory Committee on Immunization Practices (ACIP)(pages 232–235)

      Article first published online: 26 DEC 2012 | DOI: 10.1111/ajt.12073

      This document details the new recommendation for utilizing the 13-valent pneumococcal conjugate vaccine in place of the 23-valent polysaccharide vaccine in transplant recipients and the majority of candidates.

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