American Journal of Transplantation
(AM J TRANSPLANT) 《美国移植学杂志》
2015年影响因子
5.669
该杂志以论坛的形式来辩论和重新评估,是这个充满活力的领域增进了解,改善结果,推进科学进步的主要的新平台。《美国移植学杂志》每月出版,为世界各地的临床医生和研究人员提供了了重要的资源。
The journal serves as a forum for debate and re-assessment and is a major new platform for promoting understanding, improving results and advancing science in this dynamic field. Published monthly, the American Journal of Transplantation provides an essential resource for researchers and clinicians around the world.
- 2012-10-12•肺移植后康复训练可改善患者对日常活动的参与性:随机对照试验
- 2012-06-13•人类免疫缺陷病毒与丙型肝炎病毒从1名器官供者传播至4名移植受者
- 2012-05-24•常规活检发现的移植物内调节性T细胞保留着Foxp3脱甲基作用,并且是肾移植物结局的保护性生物标志物
- 2012-01-19•巨细胞病毒在同种异体肺移植物中的复制与闭塞性细支气管炎综合征有关
- 2011-10-20•十二指肠绒毛萎缩:实体器官移植后慢性腹泻的一个病因
- 2011-03-23•ABO血型相容与ABO血型不相容受者在儿科心脏移植术后的转归相似
- 2013-01-22•mTOR抑制剂同种异体移植失败和肾移植死亡率
- 2013-01-22•美国中心绩效评估和肾移植量联合会
- 2013-01-22•配型阳性活体肾移植5年结局
- 2013-01-22•瘦素通过Th2和调控免疫特征调整同种异体移植生存期
- 2013-01-22•行为经济和医疗保健提供结合点上的移植
- 2013-01-22•小RNA作为实体器官移植生物标记物
- 2016-11-02•抗CD154/CTLA4Ig共刺激阻断为主的联合治疗诱导带血管蒂肌移植的供体特异性耐受
- 2016-11-02•抗CD154/CTLA4Ig共刺激阻断为主的联合治疗诱导带血管蒂肌移植的供体特异性耐受
- 2016-11-02•抗CD154/CTLA4Ig共刺激阻断为主的联合治疗诱导带血管蒂肌移植的供体特异性耐受
- 2016-10-31•慢性排斥反应时移植物中浸润的巨噬细胞为M2型且可被嘌呤受体P2X7拮抗剂抑制
- 2016-10-31•干细胞动员剂短期治疗后的嵌合移植可使得肾移植无需免疫抑制而长期存活:一项来自小鼠的研究
- 2016-09-29•干细胞动员剂短期治疗诱导嵌合移植可使得肾移植无需免疫抑制而长期存活:一项小鼠中的研究
最新一期
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The AJT Report
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You have free access to this contentThe AJT Report: News and issues that affect organ and tissue transplantation(pages 1–2)
Article first published online: 26 DEC 2012 | DOI: 10.1111/ajt.12071
Due to privacy restrictions, the SRTR no longer has access to Social Security death data. We take a look at what this means for transplantation research and patient care, and at possible solutions. Also this month, we recount some of the papers written by 2012 Nobel laureate Alvin E. Roth published in the pages of AJT.
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Literature Watch
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You have free access to this contentLITERATURE Watch: Implications for transplantation (page 3)
Leonardo Riella and Jonathan S. Bromberg
Article first published online: 26 DEC 2012 | DOI: 10.1111/ajt.12072
One of the greatest challenges of modern science is integrating all of the knowledge derived from the identification of innumerable genes, molecules, and cells for the improvement of health; three recent papers suggest the growing field of systems biology might help translate these discoveries into tangible clinical benefits.
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Special Feature
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You have free access to this contentDr. Joseph E. Murray (1919–2012): A Life of Curiosity, Humanism, and Persistence(pages 5–6)
S. G. Tullius
Article first published online: 26 DEC 2012 | DOI: 10.1111/ajt.12076
This special tribute commemorates the father of clinical organ transplantation.
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Editorials
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You have free access to this contentBalancing Accountable Care With Risk Aversion: Transplantation as a Model (pages 7–8)
D. A. Axelrod
Article first published online: 26 DEC 2012 | DOI: 10.1111/j.1600-6143.2012.04346.x
Transplantation is widely regarded as a model of accountability and transparency in healthcare; however, failure to accurately measure and report appropriate performance metrics is likely to result in risk aversion and decreased access to transplant for higher risk populations. See also Schold et al (page 67) and Schnier et al (page 31).
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You have free access to this contentThe Cam-Path Forward (pages 9–10)
A. D. Kirk
Article first published online: 21 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04324.x
The author discusses the drug alemtuzumab as a case study in the benefits and drawbacks of off-label drug use in organ transplantation. See article by van den Hoogen et al on page 192.
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Minireviews
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You have free access to this contentMicroRNAs as Biomarkers in Solid Organ Transplantation (pages 11–19)
V. R. Mas, C. I. Dumur, M. J. Scian, R. C. Gehrau and D. G. Maluf
Article first published online: 8 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04313.x
The authors summarize recent reports detailing the identification, mechanism, clinical application and limitations of miRNAs as biomarkers in organ quality, ischemia-reperfusion injury, acute rejection, tolerance and chronic allograft dysfunction.
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You have free access to this contentDisruptions in the Supply of Medications Used in Transplantation: Implications and Management Strategies for the Transplant Clinician (pages 20–30)
J. C. Krisl, C. R. Fortier and D. J. Taber
Article first published online: 5 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04308.x
This review discusses the incidence and impact of drug shortages in solid organ transplantation and provides recommendations for transplant clinicians on appropriate therapeutic and global management of these shortages.
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Personal Viewpoint
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You have free access to this contentTransplantation at the Nexus of Behavioral Economics and Health Care Delivery(pages 31–35)
K. E. Schnier, J. C. Cox, C. McIntyre, R. Ruhil, V. Sadiraj and N. Turgeon
Article first published online: 26 DEC 2012 | DOI: 10.1111/j.1600-6143.2012.04343.x
This viewpoint discusses behavioral economic principles and how they might be applied to transplantation using a synergistic collaboration between transplant physicians and economists. See also editorial by Axelrod on page 7 and article by Schold et al on page 67.
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Original Articles
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Basic Science
You have free access to this contentLeptin Modulates Allograft Survival by Favoring a Th2 and a Regulatory Immune Profile (pages 36–44)P. M. M. Moraes-Vieira, E. J. Bassi, R. A. Larocca, A. Castoldi, M. Burghos, A. P. Lepique, F. J. Quintana, R. C. Araujo, A. S. Basso, T. B. Strom and N. O. S. Câmara
Article first published online: 27 SEP 2012 | DOI: 10.1111/j.1600-6143.2012.04283.x
The authors suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection.
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You have free access to this contentCord Blood T Cells Retain Early Differentiation Phenotype Suitable for Immunotherapy After TCR Gene Transfer to Confer EBV Specificity (pages 45–55)
G. Frumento, Y. Zheng, G. Aubert, M. Raeiszadeh, P. M. Lansdorp, P. Moss, S. P. Lee and F. E. Chen
Article first published online: 27 SEP 2012 | DOI: 10.1111/j.1600-6143.2012.04286.x
Human umbilical cord blood T cells can be redirected by T cell receptor gene transduction to target Epstein–Barr virus epitopes, and when compared in vitro with adult T cells they demonstrate properties predictive of better in vivo proliferative capacity and effector function, suggesting that cord blood can be used as a third party source of T cells for immunotherapy of posttransplant lymphoproliferative disease.
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You have free access to this contentTargeting TIM-1 on CD4 T Cells Depresses Macrophage Activation and Overcomes Ischemia-Reperfusion Injury in Mouse Orthotopic Liver Transplantation (pages 56–66)
Y. Zhang, H. Ji, X. Shen, J. Cai, F. Gao, K. M. Koenig, C. M. Batikian, R. W. Busuttil and J. W. Kupiec-Weglinski
Article first published online: 8 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04316.x
A subpopulation of activated CD4 T cells expressing the TIM-1 receptor is required to trigger hepatic damage in mouse liver transplants subjected to prolonged periods of cold storage.
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Clinical Science
You have free access to this contentThe Association of Center Performance Evaluations and Kidney Transplant Volume in the United States (pages 67–75)J. D. Schold, L. D. Buccini, T. R. Srinivas, R. T. Srinivas, E. D. Poggio, S. M. Flechner, C. Soria, D. L. Segev, J. Fung and D. A. Goldfarb
Article first published online: 26 DEC 2012 | DOI: 10.1111/j.1600-6143.2012.04345.x
There is a significant association between low performance evaluations of transplant centers in programspecific reports and a decline in kidney transplant volume. See also editorial by Axelrod on page 7 and personal viewpoint by Schnier et al on page 31.
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You have free access to this contentFive-Year Outcomes in Living Donor Kidney Transplants With a Positive Crossmatch (pages 76–85)
A. Bentall, L. D. Cornell, J. M. Gloor, W. D. Park, M. J. Gandhi, J. L. Winters, M. F. Chedid, P. G. Dean and M. D. Stegall
Article first published online: 16 OCT 2012 | DOI: 10.1111/j.1600-6143.2012.04291.x
This study demonstrates that patients with anti-class II donor-specific antibodies at baseline in positive crossmatch kidney transplants have increased early transplant glomerulopathy at one year and higher rates of graft loss compared to anti-class I antibodies alone.
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You have free access to this contentChronic Histological Damage in Early Indication Biopsies Is an Independent Risk Factor for Late Renal Allograft Failure (pages 86–99)
M. Naesens, D. R. J. Kuypers, K. De Vusser, Y. Vanrenterghem, P. Evenepoel, K. Claes, B. Bammens, B. Meijers and E. Lerut
Article first published online: 8 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04304.x
In this single-center study, the authors demonstrate that early chronic histological damage in renal allograft indication biopsies is an independent risk factor for late graft loss, irrespective of whether a specific, progressive disease is present.
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You have free access to this contentInhibitors of mTOR and Risks of Allograft Failure and Mortality in Kidney Transplantation (pages 100–110)
T. Isakova, H. Xie, S. Messinger, F. Cortazar, J. J. Scialla, G. Guerra, G. Contreras, D. Roth, G. W. Burke III, M. Z. Molnar, I. Mucsi and M. Wolf
Article first published online: 1 OCT 2012 | DOI: 10.1111/j.1600-6143.2012.04281.x
The authors conduct an observational study of 139,370 recipients who underwent kidney transplantation between 1999 and 2010 in the United States and find that compared with calcineurin-inhibitor-based regimens, use of mammalian target of rapamycin–based regimens for primary immunosuppression is associated with inferior recipient survivals.
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You have free access to this contentMedical Outcomes in African American Live Kidney Donors: A Matched Cohort Study (pages 111–118)
M. D. Doshi, M. O. Goggins, L. Li and A. X. Garg
Article first published online: 24 OCT 2012 | DOI: 10.1111/j.1600-6143.2012.04303.x
Live kidney donation is associated with increased incidence of hypertension in African Americans.
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You have free access to this contentA Surveillance Model for Skin Cancer in Organ Transplant Recipients: A 22-Year Prospective Study in an Ethnically Diverse Population (pages 119–129)
C. A. Harwood, D. Mesher, J. M. McGregor, L. Mitchell, M. Leedham-Green, M. Raftery, R. Cerio, I. M. Leigh, P. Sasieni and C. M. Proby
Article first published online: 16 OCT 2012 | DOI: 10.1111/j.1600-6143.2012.04292.x
The authors employ an evidence-based approach to skin cancer surveillance in renal transplant recipients in a singlecentre prospective study.
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You have free access to this contentValue of Routine Voiding Cystourethrography After Renal Transplantation (pages 130–135)
M. Margreiter, G. P. Györi, G. A. Böhmig, S. Trubel, F. Mühlbacher and R. Steininger
Article first published online: 27 SEP 2012 | DOI: 10.1111/j.1600-6143.2012.04284.x
By examining the value of routine voiding cystourethrography in a large cohort of kidney transplant patients, the authors show that the early vesicoureteral reflux has no meaningful effect on death-censored graft survival or overall patient survival.
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You have full text access to this OnlineOpen articlePolyomavirus BK Replication in De Novo Kidney Transplant Patients Receiving Tacrolimus or Cyclosporine: A Prospective, Randomized, Multicenter Study (pages 136–145)
H. H. Hirsch, F. Vincenti, S. Friman, M. Tuncer, F. Citterio, A. Wiecek, E. H. Scheuermann, M. Klinger, G. Russ, M. D. Pescovitz and H. Prestele
Article first published online: 8 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04320.x
In a study of kidney transplant recipients randomized 1:1 to receive either cyclosporine-A or tacrolimus together with a common backbone of basiliximab induction, mycophenolate and steroids, higher steroid exposure, tacrolimus, male gender and older age are identified as independent risk factors for BK virus in the first year posttransplant. See a related manuscript by Theodoropoulos et al on page 197.
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You have free access to this contentHigh-Quality CMV-Specific CD4+ Memory Is Enriched in the Lung Allograft and Is Associated With Mucosal Viral Control (pages 146–156)
J. A. Akulian, M. R. Pipeling, E. R. John, J. B. Orens, N. Lechtzin and J. F. McDyer
Article first published online: 27 SEP 2012 | DOI: 10.1111/j.1600-6143.2012.04282.x
This study shows that cytomegalovirus-specific CD4+ memory T cells are enriched in the lung allograft, multifunctional, and associated with mucosal viral control in lung transplant recipients.
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You have free access to this contentFunctional Status After Lung Transplantation in Older Adults in the Post-Allocation Score Era (pages 157–166)
L. Genao, H. E. Whitson, D. Zaas, L. L. Sanders and K. E. Schmader
Article first published online: 21 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04299.x
Lung transplantation has a positive effect on the functional status trajectories of both older (age 65 and higher) and younger (age 18–64) recipients, who rarely reach significant disability at 48 months posttransplantation.
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You have free access to this contentTransmission of Angiosarcomas From a Common Multiorgan Donor to Four Transplant Recipients (pages 167–173)
J. Thoning, Y. Liu, C. Bistrup, A. Thomassen, C. Borst, N. Marcussen and M. Tepel
Article first published online: 24 OCT 2012 | DOI: 10.1111/j.1600-6143.2012.04301.x
The authors describe an association of urokinase-plasminogen-activator-receptor in donor tumor transmission of metastatic angiosarcomas to four transplant recipients who received organs from an apparently unaffected, common, deceased multiorgan donor.
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You have free access to this contentComparison of De Novo Cancer Incidence in Australian Liver, Heart and Lung Transplant Recipients (pages 174–183)
R. Na, A. E. Grulich, N. S. Meagher, G. W. McCaughan, A. M. Keogh and C. M. Vajdic
Article first published online: 24 OCT 2012 | DOI: 10.1111/j.1600-6143.2012.04302.x
Cancer incidence is increased in Australian pediatric and adult liver and cardiothoracic transplant recipients, and the risk of cancer is higher in heart and lung recipients as compared to liver transplant recipients.
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You have free access to this contentLiver Transplantation Outcome in Patients With Angiographically Proven Coronary Artery Disease: A Multi-Institutional Study (pages 184–191)
C. Wray, J. C. Scovotti, J. Tobis, C. U. Niemann, R. Planinsic, A. Walia, J. Findlay, G. Wagener, J. B. Cywinski, D. Markovic, C. Hughes, A. Humar, A. Olmos, R. Sierra, R. Busuttil and R. H. Steadman
Article first published online: 5 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04293.x
The authors find no significant difference in post-liver transplant survival between patients with and without angiographically proven obstructive coronary artery disease when current treatment regimens are employed.
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Brief Communications
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You have free access to this contentTreatment of Steroid-Resistant Acute Renal Allograft Rejection With Alemtuzumab(pages 192–196)
M. W. F. van den Hoogen, D. A. Hesselink, W. J. van Son, W. Weimar and L. B. Hilbrands
Article first published online: 21 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04328.x
The authors show that alemtuzumab might be equally effective and as safe as antithymocyte globulin for the treatment of steroid-resistant renal allograft rejections, but with a significantly lower incidence of infusion-related side effects, the possibility to administer alemtuzumab subcutaneously, and lower costs. See editorial by Kirk on page 9.
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You have free access to this contentBK Virus Replication and Nephropathy After Alemtuzumab-Induced Kidney Transplantation (pages 197–206)
N. Theodoropoulos, E. Wang, S. Penugonda, D. P. Ladner, V. Stosor, J. Leventhal, J. Friedewald, M. P. Angarone and M. G. Ison
Article first published online: 8 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04314.x
This retrospective cohort study of 666 kidney transplant recipients shows that the incidence of BK viruria, viremia and nephropathy is not significantly different among kidney transplant recipients who receive alemtuzumab induction when compared to patients who receive less potent induction. See article by Hirsch et al on page 136.
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You have free access to this contentHuman Herpesvirus 8 (HHV8) Transmission and Related Morbidity in Organ Recipients (pages 207–213)
C. Lebbe, R. Porcher, A. G. Marcelin, F. Agbalika, E. Dussaix, D. Samuel, S. Varnous, S. Euvrard, A. Bigorie, H. Creusvaux, C. Legendre and C. Frances, the Skin and Organ Transplantation Group of the French Society of Dermatology
Article first published online: 11 OCT 2012 | DOI: 10.1111/j.1600-6143.2012.04290.x
This prospective French national cohort study shows a cumulative incidence of 28% of human herpesvirus-8 seroconversion among organ transplant recipients at risk of contamination, without any difference regardless of the organ transplanted, together with an overall very low prevalence of positive viremia and morbidity.
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You have free access to this contentIncidence of Primary and Second Cancers in Renal Transplant Recipients: A Multicenter Cohort Study (pages 214–221)
G. Tessari, L. Naldi, L. Boschiero, E. Minetti, S. Sandrini, F. Nacchia, F. Valerio, C. Rugiu, F. Sassi, E. Gotti, L. Fonte, G. Talamini and G. Girolomoni
Article first published online: 11 OCT 2012 | DOI: 10.1111/j.1600-6143.2012.04294.x
Renal transplant recipients are at high risk of primary and second cancers, including unusual cancers, but cancer-related mortality is not substantially increased if compared to an age- and sex-matched reference population.
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You have free access to this contentA Novel Organ Preservation for Small Partial Liver Transplantations in Rats: Venous Systemic Oxygen Persufflation With Nitric Oxide Gas (pages 222–228)
S. Yagi, K. Nagai, P. Kadaba, M. Afify, S. Teramukai, S. Uemoto and R. H. Tolba
Article first published online: 5 NOV 2012 | DOI: 10.1111/j.1600-6143.2012.04310.x
The authors report that venous systemic oxygen persufflation with nitric oxide gas is a novel, effective method for small partial liver transplantation in rats that alleviates liver graft injury and improves regeneration.
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Case Report
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You have free access to this contentTriple Red Blood Cell Alloantibody Formation After Bone-Allograft Transplantation(pages 229–231)
L. Prinzen, H. M. Staal, S. J. M. Rouwette, E. A. M. Beckers, R. H. M. ten Broeke, L. W. van Rhijn and Y. M. C. Henskens
Article first published online: 24 OCT 2012 | DOI: 10.1111/j.1600-6143.2012.04300.x
A 13-year-old boy with no history of blood transfusions developed three different rhesus alloantibodies after receiving a bone allograft, providing evidence that primary red blood cell immunization is possible after bone allograft transplantation.
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Reports From the CDC: MMWR
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You have free access to this contentUse of 13-Valent Pneumococcal Conjugate Vaccine and 23-Valent Pneumococcal Polysaccharide Vaccine for Adults With Immunocompromising Conditions: Recommendations of the Advisory Committee on Immunization Practices (ACIP)(pages 232–235)
Article first published online: 26 DEC 2012 | DOI: 10.1111/ajt.12073
This document details the new recommendation for utilizing the 13-valent pneumococcal conjugate vaccine in place of the 23-valent polysaccharide vaccine in transplant recipients and the majority of candidates.
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