血液 - 爱唯医学网

Inside Blood

- Koen van Besien
cGVHD of skin: simple tools, great advances
Blood 2012 120:2537-2538; doi:10.1182/blood-2012-07-442723
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- Charles A. Dinarello
Keep up the heat on IL-1
Blood 2012 120:2538-2539; doi:10.1182/blood-2012-08-445254
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- Klaus Podar
MM-associated anemia: more than “crowding out” HSPCs
Blood 2012 120:2539-2540; doi:10.1182/blood-2012-05-425983
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- Deepa Sampath
MiRly regulating metabolism
Blood 2012 120:2540-2541; doi:10.1182/blood-2012-08-439596
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- Benjamin S. Braun
KIT's ship comes in
Blood 2012 120:2541-2542; doi:10.1182/blood-2012-08-445247
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Blood Work

- Walter H. A. Kahr and
- Yigal Dror
Gray platelet syndrome: macrothrombocytopenia with deficient α-granules
Blood 2012 120:2543; doi:10.1182/blood-2012-03-415778
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Plenary Paper

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- David A. Jacobsohn,
- Brenda F. Kurland,
- Joseph Pidala,
- Yoshihiro Inamoto,
- Xiaoyu Chai,
- Jeanne M. Palmer,
- Sally Arai,
- Mukta Arora,
- Madan Jagasia,
- Corey Cutler,
- Daniel Weisdorf,
- Paul J. Martin,
- Steven Z. Pavletic,
- Georgia Vogelsang,
- Stephanie J. Lee,
- and Mary E. D. Flowers
CME article Correlation between NIH composite skin score, patient-reported skin score, and outcome: results from the Chronic GVHD Consortium
Blood 2012 120:2545-2552; published ahead of print July 6, 2012,doi:10.1182/blood-2012-04-424135
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Perspectives

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- Oliver Weigert and
- David M. Weinstock
The evolving contribution of hematopoietic progenitor cells to lymphomagenesis
Blood 2012 120:2553-2561; published ahead of print August 6, 2012,doi:10.1182/blood-2012-05-414995
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Review Article

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- Ripla Arora and
- Virginia E. Papaioannou
The murine allantois: a model system for the study of blood vessel formation
Blood 2012 120:2562-2572; published ahead of print July 31, 2012,doi:10.1182/blood-2012-03-390070
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Clinical Trials and Observations

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- David A. Jacobsohn,
- Brenda F. Kurland,
- Joseph Pidala,
- Yoshihiro Inamoto,
- Xiaoyu Chai,
- Jeanne M. Palmer,
- Sally Arai,
- Mukta Arora,
- Madan Jagasia,
- Corey Cutler,
- Daniel Weisdorf,
- Paul J. Martin,
- Steven Z. Pavletic,
- Georgia Vogelsang,
- Stephanie J. Lee,
- and Mary E. D. Flowers
CME article Correlation between NIH composite skin score, patient-reported skin score, and outcome: results from the Chronic GVHD Consortium
Blood 2012 120:2545-2552; published ahead of print July 6, 2012,doi:10.1182/blood-2012-04-424135
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- Jorge Cortes,
- Jeff H. Lipton,
- Delphine Rea,
- Raghunadharao Digumarti,
- Charles Chuah,
- Nisha Nanda,
- Annie-Claude Benichou,
- Adam R. Craig,
- Mauricette Michallet,
- Franck E. Nicolini,
- and Hagop Kantarjian
- , on behalf of the Omacetaxine 202 Study Group
Phase 2 study of subcutaneous omacetaxine mepesuccinate after TKI failure in patients with chronic-phase CML with T315I mutation
Blood 2012 120:2573-2580; published ahead of print August 15, 2012,doi:10.1182/blood-2012-03-415307
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- María-Victoria Mateos,
- Albert Oriol,
- Joaquín Martínez-López,
- Norma Gutiérrez,
- Ana-Isabel Teruel,
- Ana López de la Guía,
- Javier López,
- Enrique Bengoechea,
- Montserrat Pérez,
- Marta Polo,
- Luis Palomera,
- Felipe de Arriba,
- Yolanda González,
- Jose-Mariano Hernández,
- Miquel Granell,
- José-Luis Bello,
- Joan Bargay,
- Francisco-Javier Peñalver,
- José-María Ribera,
- María-Luisa Martín-Mateos,
- Ramón García-Sanz,
- Juan-José Lahuerta,
- Joan Bladé,
- and Jesús F. San-Miguel
Maintenance therapy with bortezomib plus thalidomide or bortezomib plus prednisone in elderly multiple myeloma patients included in the GEM2005MAS65 trial
Blood 2012 120:2581-2588; published ahead of print August 13, 2012,doi:10.1182/blood-2012-05-427815
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- Hervé Ghesquières,
- Guillaume Cartron,
- John Francis Seymour,
- Marie-Hélène Delfau-Larue,
- Fritz Offner,
- Pierre Soubeyran,
- Aurore Perrot,
- Pauline Brice,
- Réda Bouabdallah,
- Anne Sonet,
- Jehan Dupuis,
- Olivier Casasnovas,
- John Vincent Catalano,
- Alain Delmer,
- Fabrice Jardin,
- Aurélie Verney,
- Peggy Dartigues,
- and Gilles Salles
Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected byFCGR3A and FCGR2A polymorphisms
Blood 2012 120:2650-2657; published ahead of print August 10, 2012,doi:10.1182/blood-2012-05-431825
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Hematopoiesis and Stem Cells

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- Charlie Mantel,
- Steven Messina-Graham,
- Akira Moh,
- Scott Cooper,
- Giao Hangoc,
- Xin-Yuan Fu,
- and Hal E. Broxmeyer
Mouse hematopoietic cell–targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging–like phenotype
Blood 2012 120:2589-2599; published ahead of print June 4, 2012,doi:10.1182/blood-2012-01-404004
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- Maegan L. Capitano,
- Michael J. Nemeth,
- Thomas A. Mace,
- Christi Salisbury-Ruf,
- Brahm H. Segal,
- Philip L. McCarthy,
- and Elizabeth A. Repasky
Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1–, IL-17–, and G-CSF–dependent manner
Blood 2012 120:2600-2609; published ahead of print July 17, 2012,doi:10.1182/blood-2012-02-409805
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- Hyung Joon Joo,
- Dong-Kyu Choi,
- Joon Seo Lim,
- Jin-Sung Park,
- Seung-Hun Lee,
- Sukhyun Song,
- Jennifer H. Shin,
- Do-Sun Lim,
- Injune Kim,
- Ki-Chul Hwang,
- and Gou Young Koh
ROCK suppression promotes differentiation and expansion of endothelial cells from embryonic stem cell–derived Flk1⁺mesodermal precursor cells
Blood 2012 120:2733-2744; published ahead of print August 14, 2012,doi:10.1182/blood-2012-04-421610
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- Jennifer L. Gori,
- Devikha Chandrasekaran,
- John P. Kowalski,
- Jennifer E. Adair,
- Brian C. Beard,
- Sunita L. D'Souza,
- and Hans-Peter Kiem
e-Blood Efficient generation, purification, and expansion of CD34⁺ hematopoietic progenitor cells from nonhuman primate–induced pluripotent stem cells
Blood 2012 120:e35-e44; published ahead of print August 16, 2012,doi:10.1182/blood-2012-05-433797
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Immunobiology

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- Raffaello Cimbro,
- Lia Vassena,
- James Arthos,
- Claudia Cicala,
- John H. Kehrl,
- Chung Park,
- Irini Sereti,
- Michael M. Lederman,
- Anthony S. Fauci,
- and Paolo Lusso
IL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosa
Blood 2012 120:2610-2619; published ahead of print August 14, 2012,doi:10.1182/blood-2012-06-434779
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Lymphoid Neoplasia

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- María-Victoria Mateos,
- Albert Oriol,
- Joaquín Martínez-López,
- Norma Gutiérrez,
- Ana-Isabel Teruel,
- Ana López de la Guía,
- Javier López,
- Enrique Bengoechea,
- Montserrat Pérez,
- Marta Polo,
- Luis Palomera,
- Felipe de Arriba,
- Yolanda González,
- Jose-Mariano Hernández,
- Miquel Granell,
- José-Luis Bello,
- Joan Bargay,
- Francisco-Javier Peñalver,
- José-María Ribera,
- María-Luisa Martín-Mateos,
- Ramón García-Sanz,
- Juan-José Lahuerta,
- Joan Bladé,
- and Jesús F. San-Miguel
Maintenance therapy with bortezomib plus thalidomide or bortezomib plus prednisone in elderly multiple myeloma patients included in the GEM2005MAS65 trial
Blood 2012 120:2581-2588; published ahead of print August 13, 2012,doi:10.1182/blood-2012-05-427815
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- Ingmar Bruns,
- Ron-Patrick Cadeddu,
- Ines Brueckmann,
- Julia Fröbel,
- Stefanie Geyh,
- Sebastian Büst,
- Johannes C. Fischer,
- Frederik Roels,
- Christian Matthias Wilk,
- Frank A. Schildberg,
- Ali-Nuri Hünerlitürkoglu,
- Christoph Zilkens,
- Marcus Jäger,
- Ulrich Steidl,
- Fabian Zohren,
- Roland Fenk,
- Guido Kobbe,
- Benedict Brors,
- Akos Czibere,
- Thomas Schroeder,
- Andreas Trumpp,
- and Rainer Haas
Multiple myeloma–related deregulation of bone marrow–derived CD34⁺ hematopoietic stem and progenitor cells
Blood 2012 120:2620-2630; published ahead of print April 18, 2012,doi:10.1182/blood-2011-04-347484
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- Esmerina Tili,
- Jean-Jacques Michaille,
- Zhenghua Luo,
- Stefano Volinia,
- Laura Z. Rassenti,
- Thomas J. Kipps,
- and Carlo M. Croce
The down-regulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed state
Blood 2012 120:2631-2638; published ahead of print June 21, 2012,doi:10.1182/blood-2012-03-415737
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- Han-Yu Chuang,
- Laura Rassenti,
- Michelle Salcedo,
- Kate Licon,
- Alexander Kohlmann,
- Torsten Haferlach,
- Robin Foà,
- Trey Ideker,
- and Thomas J. Kipps
Subnetwork-based analysis of chronic lymphocytic leukemia identifies pathways that associate with disease progression
Blood 2012 120:2639-2649; published ahead of print July 26, 2012,doi:10.1182/blood-2012-03-416461
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- Hervé Ghesquières,
- Guillaume Cartron,
- John Francis Seymour,
- Marie-Hélène Delfau-Larue,
- Fritz Offner,
- Pierre Soubeyran,
- Aurore Perrot,
- Pauline Brice,
- Réda Bouabdallah,
- Anne Sonet,
- Jehan Dupuis,
- Olivier Casasnovas,
- John Vincent Catalano,
- Alain Delmer,
- Fabrice Jardin,
- Aurélie Verney,
- Peggy Dartigues,
- and Gilles Salles
Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected byFCGR3A and FCGR2A polymorphisms
Blood 2012 120:2650-2657; published ahead of print August 10, 2012,doi:10.1182/blood-2012-05-431825
- Abstract
- Full Text
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Myeloid Neoplasia

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- Jorge Cortes,
- Jeff H. Lipton,
- Delphine Rea,
- Raghunadharao Digumarti,
- Charles Chuah,
- Nisha Nanda,
- Annie-Claude Benichou,
- Adam R. Craig,
- Mauricette Michallet,
- Franck E. Nicolini,
- and Hagop Kantarjian
- , on behalf of the Omacetaxine 202 Study Group
Phase 2 study of subcutaneous omacetaxine mepesuccinate after TKI failure in patients with chronic-phase CML with T315I mutation
Blood 2012 120:2573-2580; published ahead of print August 15, 2012,doi:10.1182/blood-2012-03-415307
- Abstract
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- Supplemental Appendix
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- Anupriya Agarwal,
- Angela G. Fleischman,
- Curtis L. Petersen,
- Ryan MacKenzie,
- Samuel Luty,
- Marc Loriaux,
- Brian J. Druker,
- Randall L. Woltjer,
- and Michael W. Deininger
Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML
Blood 2012 120:2658-2668; published ahead of print August 13, 2012,doi:10.1182/blood-2011-05-355396
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- Raghuveer Singh Mali,
- Peilin Ma,
- Li-Fan Zeng,
- Holly Martin,
- Baskar Ramdas,
- Yantao He,
- Emily Sims,
- Sarah Nabinger,
- Joydeep Ghosh,
- Namit Sharma,
- Veerendra Munugalavadla,
- Anindya Chatterjee,
- Shuo Li,
- George Sandusky,
- Andrew W. Craig,
- Kevin D. Bunting,
- Gen-Sheng Feng,
- Rebecca J. Chan,
- Zhong-Yin Zhang,
- and Reuben Kapur
Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT
Blood 2012 120:2669-2678; published ahead of print July 17, 2012,doi:10.1182/blood-2011-08-375873
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- Zhihong Zeng,
- Yue Xi Shi,
- Twee Tsao,
- YiHua Qiu,
- Steven M. Kornblau,
- Keith A. Baggerly,
- Wenbin Liu,
- Katti Jessen,
- Yi Liu,
- Hagop Kantarjian,
- Christian Rommel,
- David A. Fruman,
- Michael Andreeff,
- and Marina Konopleva
Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment
Blood 2012 120:2679-2689; published ahead of print July 23, 2012,doi:10.1182/blood-2011-11-393934
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- Sarah Mans,
- Yara Banz,
- Beatrice U. Mueller,
- and Thomas Pabst
The angiogenesis inhibitor vasostatin is regulated by neutrophil elastase–dependent cleavage of calreticulin in AML patients
Blood 2012 120:2690-2699; published ahead of print August 22, 2012,doi:10.1182/blood-2012-02-412759
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- Julien Haroche,
- Frédéric Charlotte,
- Laurent Arnaud,
- Andreas von Deimling,
- Zofia Hélias-Rodzewicz,
- Baptiste Hervier,
- Fleur Cohen-Aubart,
- David Launay,
- Annette Lesot,
- Karima Mokhtari,
- Danielle Canioni,
- Louise Galmiche,
- Christian Rose,
- Marc Schmalzing,
- Sandra Croockewit,
- Marianne Kambouchner,
- Marie-Christine Copin,
- Sylvie Fraitag,
- Felix Sahm,
- Nicole Brousse,
- Zahir Amoura,
- Jean Donadieu,
- and Jean-François Emile
Brief report High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses
Blood 2012 120:2700-2703; published ahead of print August 9, 2012,doi:10.1182/blood-2012-05-430140
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- Anna L. Godfrey,
- Edwin Chen,
- Francesca Pagano,
- Christina A. Ortmann,
- Yvonne Silber,
- Beatriz Bellosillo,
- Paola Guglielmelli,
- Claire N. Harrison,
- John T. Reilly,
- Frank Stegelmann,
- Fontanet Bijou,
- Eric Lippert,
- Mary F. McMullin,
- Jean-Michel Boiron,
- Konstanze Döhner,
- Alessandro M. Vannucchi,
- Carlos Besses,
- Peter J. Campbell,
- and Anthony R. Green
Brief report JAK2V617F homozygosity arises commonly and recurrently in PV and ET, but PV is characterized by expansion of a dominant homozygous subclone
Blood 2012 120:2704-2707; published ahead of print August 16, 2012,doi:10.1182/blood-2012-05-431791
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Phagocytes, Granulocytes, and Myelopoiesis

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- Maegan L. Capitano,
- Michael J. Nemeth,
- Thomas A. Mace,
- Christi Salisbury-Ruf,
- Brahm H. Segal,
- Philip L. McCarthy,
- and Elizabeth A. Repasky
Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1–, IL-17–, and G-CSF–dependent manner
Blood 2012 120:2600-2609; published ahead of print July 17, 2012,doi:10.1182/blood-2012-02-409805
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- Julien Haroche,
- Frédéric Charlotte,
- Laurent Arnaud,
- Andreas von Deimling,
- Zofia Hélias-Rodzewicz,
- Baptiste Hervier,
- Fleur Cohen-Aubart,
- David Launay,
- Annette Lesot,
- Karima Mokhtari,
- Danielle Canioni,
- Louise Galmiche,
- Christian Rose,
- Marc Schmalzing,
- Sandra Croockewit,
- Marianne Kambouchner,
- Marie-Christine Copin,
- Sylvie Fraitag,
- Felix Sahm,
- Nicole Brousse,
- Zahir Amoura,
- Jean Donadieu,
- and Jean-François Emile
Brief report High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses
Blood 2012 120:2700-2703; published ahead of print August 9, 2012,doi:10.1182/blood-2012-05-430140
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Platelets and Thrombopoiesis

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- Dominique Bluteau,
- Ana C. Glembotsky,
- Anna Raimbault,
- Nathalie Balayn,
- Laure Gilles,
- Philippe Rameau,
- Paquita Nurden,
- Marie Christine Alessi,
- Najet Debili,
- William Vainchenker,
- Paula G. Heller,
- Remi Favier,
- and Hana Raslova
Dysmegakaryopoiesis of FPD/AML pedigrees with constitutionalRUNX1 mutations is linked to myosin II deregulated expression
Blood 2012 120:2708-2718; published ahead of print August 16, 2012,doi:10.1182/blood-2012-04-422337
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- Iléana Antony-Debré,
- Dominique Bluteau,
- Raphael Itzykson,
- Véronique Baccini,
- Aline Renneville,
- Françoise Boehlen,
- Margot Morabito,
- Nathalie Droin,
- Caroline Deswarte,
- Yunhua Chang,
- Guy Leverger,
- Eric Solary,
- William Vainchenker,
- Rémi Favier,
- and Hana Raslova
Brief report MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations
Blood 2012 120:2719-2722; published ahead of print June 7, 2012,doi:10.1182/blood-2012-04-422352
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Thrombosis and Hemostasis

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- Ana-Maria Navarrete,
- Caterina Casari,
- Paulette Legendre,
- Isabelle Marx,
- Jiun-Ruey Hu,
- Peter J. Lenting,
- Olivier D. Christophe,
- and Cécile V. Denis
A murine model to characterize the antithrombotic effect of molecules targeting human von Willebrand factor
Blood 2012 120:2723-2732; published ahead of print August 20, 2012,doi:10.1182/blood-2012-03-420042
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Transplantation

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- David A. Jacobsohn,
- Brenda F. Kurland,
- Joseph Pidala,
- Yoshihiro Inamoto,
- Xiaoyu Chai,
- Jeanne M. Palmer,
- Sally Arai,
- Mukta Arora,
- Madan Jagasia,
- Corey Cutler,
- Daniel Weisdorf,
- Paul J. Martin,
- Steven Z. Pavletic,
- Georgia Vogelsang,
- Stephanie J. Lee,
- and Mary E. D. Flowers
CME article Correlation between NIH composite skin score, patient-reported skin score, and outcome: results from the Chronic GVHD Consortium
Blood 2012 120:2545-2552; published ahead of print July 6, 2012,doi:10.1182/blood-2012-04-424135
- Abstract
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- Supplemental Figure

Vascular Biology

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- Hyung Joon Joo,
- Dong-Kyu Choi,
- Joon Seo Lim,
- Jin-Sung Park,
- Seung-Hun Lee,
- Sukhyun Song,
- Jennifer H. Shin,
- Do-Sun Lim,
- Injune Kim,
- Ki-Chul Hwang,
- and Gou Young Koh
ROCK suppression promotes differentiation and expansion of endothelial cells from embryonic stem cell–derived Flk1⁺mesodermal precursor cells
Blood 2012 120:2733-2744; published ahead of print August 14, 2012,doi:10.1182/blood-2012-04-421610
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- Kathleen Spring,
- Catherine Chabot,
- Simon Langlois,
- Line Lapointe,
- Nguyen Thu Ngan Trinh,
- Christine Caron,
- Jagoda K. Hebda,
- Julie Gavard,
- Mounib Elchebly,
- and Isabelle Royal
Tyrosine phosphorylation of DEP-1/CD148 as a mechanism controlling Src kinase activation, endothelial cell permeability, invasion, and capillary formation
Blood 2012 120:2745-2756; published ahead of print August 16, 2012,doi:10.1182/blood-2011-12-398040
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- Ruben Bierings,
- Nicola Hellen,
- Nikolai Kiskin,
- Laura Knipe,
- Ana-Violeta Fonseca,
- Bijal Patel,
- Athina Meli,
- Marlene Rose,
- Matthew J. Hannah,
- and Tom Carter
The interplay between the Rab27A effectors Slp4-a and MyRIP controls hormone-evoked Weibel-Palade body exocytosis
Blood 2012 120:2757-2767; published ahead of print August 16, 2012,doi:10.1182/blood-2012-05-429936
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Correspondence

- Ohad Benjamini,
- Preetesh Jain,
- Zeev Estrov,
- Hagop M. Kantarjian,
- and Srdan Verstovsek
Therapeutic effects of ruxolitinib in patients with myelofibrosis without clinically significant splenomegaly
Blood 2012 120:2768-2769; doi:10.1182/blood-2012-07-446849
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- Patrick Trépanier and
- Renée Bazin
Intravenous immunoglobulin (IVIg) inhibits CD8 cytotoxic T-cell activation
Blood 2012 120:2769-2770; doi:10.1182/blood-2012-07-445007
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- Florian Babor,
- Angela Manser,
- Kathrin Schönberg,
- Jürgen Enczmann,
- Arndt Borkhardt,
- Roland Meisel,
- and Markus Uhrberg
Lack of association between KIR genes and acute lymphoblastic leukemia in children
Blood 2012 120:2770-2772; doi:10.1182/blood-2012-07-440495
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- Suzanne Samarani and
- Ali Ahmad
Response: associations between activating KIR genes and childhood leukemia
Blood 2012 120:2772; doi:10.1182/blood-2012-08-444588
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Errata

- Maria Teresa Sabrina Bertilaccio,
- Giorgia Simonetti,
- Antonis Dagklis,
- Martina Rocchi,
- Tania Veliz Rodriguez,
- Benedetta Apollonio,
- Alberto Mantovani,
- Maurilio Ponzoni,
- Paolo Ghia,
- Cecilia Garlanda,
- Federico Caligaris-Cappio,
- and Marta Muzio
Bertilaccio MT, Simonetti G, Dagklis A, et al. Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models. Blood. 2011;118(3):660–669.
Blood 2012 120:2773; doi:10.1182/blood-2012-08-447797
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Other Departments

Continuing Medical Education (CME) questions: response measures in skin chronic GVHD
Blood 2012 120:2774; doi:10.1182/blood-2012-08-451260
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Blood (BLOOD) 《血液 》

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Inside Blood

cGVHD of skin: simple tools, great advances

Keep up the heat on IL-1

MM-associated anemia: more than “crowding out” HSPCs

MiRly regulating metabolism

KIT's ship comes in

Blood Work

Gray platelet syndrome: macrothrombocytopenia with deficient α-granules

Plenary Paper

CME article Correlation between NIH composite skin score, patient-reported skin score, and outcome: results from the Chronic GVHD Consortium

Perspectives

The evolving contribution of hematopoietic progenitor cells to lymphomagenesis

Review Article

The murine allantois: a model system for the study of blood vessel formation

Clinical Trials and Observations

CME article Correlation between NIH composite skin score, patient-reported skin score, and outcome: results from the Chronic GVHD Consortium

Phase 2 study of subcutaneous omacetaxine mepesuccinate after TKI failure in patients with chronic-phase CML with T315I mutation

Maintenance therapy with bortezomib plus thalidomide or bortezomib plus prednisone in elderly multiple myeloma patients included in the GEM2005MAS65 trial

Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected byFCGR3A and FCGR2A polymorphisms

Hematopoiesis and Stem Cells

Mouse hematopoietic cell–targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging–like phenotype

Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1–, IL-17–, and G-CSF–dependent manner

ROCK suppression promotes differentiation and expansion of endothelial cells from embryonic stem cell–derived Flk1+mesodermal precursor cells

e-Blood Efficient generation, purification, and expansion of CD34+ hematopoietic progenitor cells from nonhuman primate–induced pluripotent stem cells

Immunobiology

IL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosa

Lymphoid Neoplasia

Maintenance therapy with bortezomib plus thalidomide or bortezomib plus prednisone in elderly multiple myeloma patients included in the GEM2005MAS65 trial

Multiple myeloma–related deregulation of bone marrow–derived CD34+ hematopoietic stem and progenitor cells

The down-regulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed state

Subnetwork-based analysis of chronic lymphocytic leukemia identifies pathways that associate with disease progression

Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected byFCGR3A and FCGR2A polymorphisms

Myeloid Neoplasia

Phase 2 study of subcutaneous omacetaxine mepesuccinate after TKI failure in patients with chronic-phase CML with T315I mutation

Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML

Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment

The angiogenesis inhibitor vasostatin is regulated by neutrophil elastase–dependent cleavage of calreticulin in AML patients

Brief report High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses

Brief report JAK2V617F homozygosity arises commonly and recurrently in PV and ET, but PV is characterized by expansion of a dominant homozygous subclone

Phagocytes, Granulocytes, and Myelopoiesis

Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1–, IL-17–, and G-CSF–dependent manner

Brief report High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses

Platelets and Thrombopoiesis

Dysmegakaryopoiesis of FPD/AML pedigrees with constitutionalRUNX1 mutations is linked to myosin II deregulated expression

Brief report MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations

Thrombosis and Hemostasis

A murine model to characterize the antithrombotic effect of molecules targeting human von Willebrand factor

Transplantation

CME article Correlation between NIH composite skin score, patient-reported skin score, and outcome: results from the Chronic GVHD Consortium

Vascular Biology

ROCK suppression promotes differentiation and expansion of endothelial cells from embryonic stem cell–derived Flk1+mesodermal precursor cells

Tyrosine phosphorylation of DEP-1/CD148 as a mechanism controlling Src kinase activation, endothelial cell permeability, invasion, and capillary formation

The interplay between the Rab27A effectors Slp4-a and MyRIP controls hormone-evoked Weibel-Palade body exocytosis

Correspondence

Therapeutic effects of ruxolitinib in patients with myelofibrosis without clinically significant splenomegaly

Intravenous immunoglobulin (IVIg) inhibits CD8 cytotoxic T-cell activation

Lack of association between KIR genes and acute lymphoblastic leukemia in children

Response: associations between activating KIR genes and childhood leukemia

Errata

Bertilaccio MT, Simonetti G, Dagklis A, et al. Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models. Blood. 2011;118(3):660–669.

Other Departments

Continuing Medical Education (CME) questions: response measures in skin chronic GVHD

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Blood
(BLOOD) 《血液》

ROCK suppression promotes differentiation and expansion of endothelial cells from embryonic stem cell–derived Flk1⁺mesodermal precursor cells

e-Blood Efficient generation, purification, and expansion of CD34⁺ hematopoietic progenitor cells from nonhuman primate–induced pluripotent stem cells

Multiple myeloma–related deregulation of bone marrow–derived CD34⁺ hematopoietic stem and progenitor cells

ROCK suppression promotes differentiation and expansion of endothelial cells from embryonic stem cell–derived Flk1⁺mesodermal precursor cells