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Journal of Autoimmunity
(J AUTOIMMUN) 《自身免疫杂志》

自身免疫杂志
2012年影响因子
8.145
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Published 2012年9月,Volume 39,Issue 3

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Special Issue on Pierre Youinou: The intersection of Intuition, Determination and Autoimmunity
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Pierre Youinou: When intuition and determination meet autoimmunity


Pages 117-120
Christophe Jamin, Yves Renaudineau, Jacques-Olivier Pers
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Factor XI is a substrate for oxidoreductases: Enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosis

 Original Research Article
Pages 121-129
Bill Giannakopoulos, Lu Gao, Miao Qi, Jason W. Wong, Demin M. Yu, Panayiotis G. Vlachoyiannopoulos, Harry M. Moutsopoulos, Tatsuya Atsumi, Takao Koike, Philip Hogg, Jian C. Qi, Steven A. Krilis
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Highlights

► Factor XI can be reduced by oxidorectases such as thioredoxin. ► Thioredoxin potentiates thrombin activation of FXI to its active form FXIa. ► Reduced FXI circulates in human plasma and is significantly elevated in patients with APS. ► These data suggest a mechanism for the venous and arterial thrombosis seen in patients with APS.
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Role of TWEAK in lupus nephritis: A bench-to-bedside review

 Review Article
Pages 130-142
Jennifer S. Michaelson, Nicolas Wisniacki, Linda C. Burkly, Chaim Putterman
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► TWEAK (TNFSF12) can contribute to several mechanisms important in lupus nephritis. ► TWEAK promotes inflammation, cell activation/proliferation/apoptosis, and fibrosis. ► Inhibiting TWEAK signaling is beneficial in multiple animal models of nephritis. ► Kidney expression of TWEAK and Fn14 is increased in human lupus nephritis. ► Anti-TWEAK therapy is being developed as a novel approach in human lupus nephritis.
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Peptide-based approaches to treat lupus and other autoimmune diseases

 Review Article
Pages 143-153
Nicolas Schall, Nicolas Page, Christophe Macri, Olivier Chaloin, Jean-Paul Briand, Sylviane Muller
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► Synthetic peptides are facing a long avenue of interest for therapeutic applications. ► The phosphopeptide P140 improves the clinical and biological features of lupus mice. ► P140 influences the autophagic flux in APCs and destabilizes MHC molecules. ► The nature of excipient used to administrate a bioactive peptide is critical. ► The peptide P140/Lupuzor has successfully completed phase IIb clinical trial for SLE.
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Altered patterns of epigenetic changes in systemic lupus erythematosus and auto-antibody production: Is there a link?

 Review Article
Pages 154-160
Yosra Thabet, Felipe Cañas, Ibtissem Ghedira, Pierre Youinou, Rizgar A. Mageed, Yves Renaudineau
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► Epigenetic alterations are important in the pathogenesis of SLE. ► Epigenetic modifications and auto-antibody production may be linked. ► Hypomethylated DNA is immunogenic and recognized by autoantibodies. ► Anti-histone antibodies bind preferentially epigenetic-sensitive hot spots. ► Epigenetically-modified ribonucleoprotein are important target for autoantibodies.
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B cells in Sjögren's syndrome: From pathophysiology to diagnosis and treatment

 Review Article
Pages 161-167
Divi Cornec, Valérie Devauchelle-Pensec, Gabriel J. Tobón, Jacques-Olivier Pers, Sandrine Jousse-Joulin, Alain Saraux
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► Recent data demonstrated the central roles of B cells in the pathogenesis of pSS. ► Peripheral blood and salivary-gland B-cell subset distribution is altered during pSS. ► The cytokine BAFF is instrumental in the occurrence of B-cell dysfunction. ► Autoantibodies and blood B-cell subset analysis are important for the diagnosis. ► B-cell directed therapies hold promise in the treatment of the disease.
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Effect of IVIg on human dendritic cell-mediated antigen uptake and presentation: Role of lipid accumulation

 Original Research Article
Pages 168-172
Shivashankar Othy, Patrick Bruneval, Selma Topçu, Isabelle Dugail, Francisco Delers, Sebastien Lacroix-Desmazes, Jagadeesh Bayry, Srini V. Kaveri
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► High dose of IVIg inhibits uptake and processing of antigens by dendritic cells. ► IVIg increases accumulation of lipids in dendritic cells. ► DC generated in presence of IVIg uptake more lipids.
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TLR9 drives the development of transitional B cells towards the marginal zone pathway and promotes autoimmunity

 Original Research Article
Pages 173-179
Thomas Guerrier, Pierre Youinou, Jacques-Olivier Pers, Christophe Jamin
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► Transitional and mature B cells proliferate in response to TLR9 stimulation. ► TLR9 specifically differentiate transitional B cells into MZ B cells. ► TLR9-stimulated transitional B cells produce autoreactive antibodies.
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Bone marrow of NZB/W mice is the major site for plasma cells resistant to dexamethasone and cyclophosphamide: Implications for the treatment of autoimmunity

 Original Research Article
Pages 180-188
Imtiaz M. Mumtaz, Bimba F. Hoyer, Daniel Panne, Katrin Moser, Oliver Winter, Qingyu Y. Cheng, Taketoshi Yoshida, Gerd-R. Burmester, Andreas Radbruch, Rudolf A. Manz, Falk Hiepe
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► Autoreactive plasma cells are localized in spleen, inflamed kidneys and bone marrow. ► The bone marrow is the major site of memory plasma cells. ► These cells are resistant to glucocorticoids and anti-proliferative drugs. ► Therapeutic strategies should consider targeting autoreactive memory plasma cells.
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The complexity of the BAFF TNF-family members: Implications for autoimmunity

 Review Article
Pages 189-198
Ayan Lahiri, Pierre Pochard, Laëtitia Le Pottier, Gabriel J. Tobón, Boutahar Bendaoud, Pierre Youinou, Jacques-Olivier Pers
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► BAFF offers a cluster of variants and forms. ► BAFF can be membrane bound or soluble, glycosylated or non-glycosylated. ► BAFF can form monomer or trimers (heterotrimers with APRIL or BAFF variants). ► ΔBAFF suppresses BAFF function whereas Δ4BAFF favors BAFF transcription. ► Differences between BAFF forms could modulate the effects of anti-BAFF therapy.
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Sjögren’s syndrome at the crossroad of polyautoimmunity

 Original Research Article
Pages 199-205
Manuel J. Amador-Patarroyo, Juan Guillermo Arbelaez, Ruben D. Mantilla, Alberto Rodriguez-Rodriguez, Jorge Cárdenas-Roldán, Ricardo Pineda-Tamayo, Mayra R. Guarin, Liliana Lopez Kleine, Adriana Rojas-Villarraga, Juan-Manuel Anaya
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► Polyautoimmunity (PA) is frequent in SS and follows a grouping pattern. ► Duration of disease, smoking and history of abortions are risk factors for PA in SS. ► Clustering of PA in SS and others ADs will help find common mechanisms among them.
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Regulatory NK cells in autoimmune disease

 Review Article
Pages 206-215
Zhigang Tian, M. Eric Gershwin, Cai Zhang
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► There is genetic correlation of autoimmune diseases with NK cell receptor/ligands. ► NK cells play important role in maintenance of homeostasis. ► Misrecognition of NK cells may contribute to pathogenesis of autoimmune diseases. ► NK cells seemed to act as a two edged weapon in autoimmune diseases.
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The immunopathology of liver granulomas in primary biliary cirrhosis

 Original Research Article
Pages 216-221
Zhengrui You, Qixia Wang, Zhaolian Bian, Yuan Liu, Xiaofeng Han, Yanshen Peng, Lei Shen, Xiaoyu Chen, Dekai Qiu, Carlo Selmi, M. Eric Gershwin, Xiong Ma
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► Dendritic cell marker CD11c is highly expressed in granulomas associated with PBC. ► Epithelioid cells within granulomas share features of immature DC. ► PBC with CD11c+ granulomas have higher serum IgM levels and earlier disease stages. ► B cells and IgM+ plasma cells are largely represented around PBC granulomas.
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Rheumatoid arthritis: From autoimmunity to synovitis and joint destruction

 Review Article
Pages 222-228
Marie-Christophe Boissier, Luca Semerano, Salima Challal, Nathalie Saidenberg-Kermanac'h, Géraldine Falgarone
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► Autoimmunity in rheumatoid arthritis targets post-translational citrullination. ► Tobacco is a link between environment, genes, and autoimmunity. ► Innate immunity is highly stimulated and appears by itself a target for treatments. ► Tissue destruction is not only the result of chronic inflammation and involves specific mechanisms.
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The T cell in Sjogren's syndrome: Force majeure, not spectateur

 Review Article
Pages 229-233
Namrata Singh, Philip L. Cohen
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► T cells are the majority of lymphocytes in Sjogren's infiltrates. ► T cells secrete Th1 and Th2 cytokines. ► Th17 T cells actively contribute to Sjogren pathology. ► Defective T regulatory cells play a role in disease. ► T cells can directly injure glands through cytotoxicity.
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Low levels of vitamin-D are associated with neuropathy and lymphoma among patients with Sjögren’s syndrome

 Original Research Article
Pages 234-239
Nancy Agmon-Levin, Shaye Kivity, Athanasios G. Tzioufas, Marcus López Hoyos, Blaz Rozman, Inga Efes, Yinon Shapira, Ari Shamis, Howard Amital, Pierre Youinou, Yehuda Shoenfeld
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► Vitamin-D levels of Sjogren's syn. patients do not differ from the healthy population. ► Peripheral neuropathy was diagnosed in 23% of Sjogren’s syn. patients in this cohort. ► Lymphoma was diagnosed in 4.3% of Sjogren’s syn. patients. ► Peripheral neuropathy and lymphoma were associated with lower vitamin-D levels.
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T cells, murine chronic graft-versus-host disease and autoimmunity

 Review Article
Pages 240-247
Robert A. Eisenberg, Charles S. Via
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