For seasonal flu vaccines that will be developed for use in the southern hemisphere in 2010, the World Health Organization recommends replacing the H1N1 strain in the current seasonal flu vaccine with a pandemic influenza A(H1N1) strain.
The three strains recommended by the WHO for inclusion in the southern hemisphere 2010 influenza vaccine are: A/California/7/2009 (H1N1)-like virus, A/Perth/16/2009 (H3N2)-like virus, and B/Brisbane/60/2008-like virus. The information was included in a WHO report released Sept 23.
The pandemic H1N1 virus was the dominant flu strain circulating in most of the world by July 2009, the WHO said in its technical report on the 2010 strain recommendations.
“Although it is impossible to know whether the seasonal influenza A(H1N1) viruses will be completely replaced by the pandemic influenza A(H1N1) virus, the group of experts convened by WHO for this consultation consider it likely that seasonal influenza A(H1N1) will not pose a major public health risk in 2010 in the southern hemisphere,” the WHO said in a question-and-answer statement.
The WHO��s Strategic Group of Experts (SAGE) will meet in late October to discuss whether the three strains should be combined into a single trivalent vaccine or whether separate vaccines should be developed for seasonal and pandemic flu, according to the statement. The priority groups for the seasonal and pandemic flu differ slightly, which raises the possibility of two separate vaccines next year.
A majority of the H1N1 viruses seen so far have been sensitive to the neuraminidase inhibitors oseltamivir and zanamivir, according to the technical report. The WHO will make recommendations in February 2010 for flu vaccines for use in the northern hemisphere in 2010.
View the complete WHO report and data on the extent and type of flu activity worldwide from February to August 2009 at www.who.int.
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由于将研制针对2010年南半球的季节性流感疫苗，世界卫生组织（WHO）建议将目前的季节性流感疫苗中H1N1病毒株替换为一种大流行甲型H1N1流感病毒株。
WHO推荐的2010年南半球流感疫苗所包含的3种病毒株为：A型/California/7/2009 (H1N1)类似株、A型/Perth/16/2009 (H3N2)类似株和B型/Brisbane/60/2008类似株。有关信息可以在WHO 9月23日公布的报告中查到。
WHO在其关于2010年病毒株建议的技术报告中说，此种大流行H1N1病毒株是一种截至2009年7月世界大多数地区流行的主要流感病毒株。
“虽然目前还不能确定（目前疫苗中的）季节性甲型H1N1流感病毒株是否会被这种大流行甲型H1N1流感病毒株完全代替，但WHO召集的专家咨询组认为季节性甲型H1N1流感很可能不会是威胁2010年南半球公众健康的主要因素”WHO在一份问答形式的声明中说。
此外，这项声明中还提到，WHO的策略研究专家组（SAGE）将在10月份后期召开会议，讨论是研制一种三联疫苗同时针对3种病毒株，还是分别单独开发针对季节性流感及大流行流感的疫苗。由于针对季节性流感和大流行流感的重点接种人群有少许不同，这使明年分别采用两种方案的可能性更大一些。
WHO的技术报告中说，目前大部分H1N1病毒株对神经氨酸酶抑制剂奥司他韦及扎那米韦敏感。2010年2月WHO将提出北半球的2010年流感疫苗建议方案。
WHO完整报告、进一步数据及2009年2～8月的世界各地区流感活动类型可以在WHO官方网站www.who.int上查到。
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