Only one in four women diagnosed with breast cancer in the 1940s was alive 10 years later, compared with three of four women diagnosed in recent years, based on data gathered over a 6-decade period at a single institution.

Overall, the 10-year survival rate for all types of breast cancer improved significantly over 60 years, from 25% between 1944 and 1954, to 77% between 1995 and 2004. This improvement is because of earlier disease detection and a multimodal approach to managing and treating patients with different stages of breast cancer, Dr. Aman Buzdar, the study’s lead author, reported Sept. 29.

The goal of the study was to quantify the steady improvements in breast cancer survival rates over the past 6 decades in patients seen at the MD Anderson Cancer Center in Houston. Dr. Buzdar said he believes that the survival rates seen at MD Anderson are generalizable to survival rates at smaller regional hospitals and community cancer centers, given the rapid adoption of the multimodal treatment model and new therapies.

“If patients are appropriately managed, they have a much better chance of surviving breast cancer today than they would have had 30 or 20 or even 10 years ago, because the therapies are constantly evolving and improving,” Dr. Buzdar, professor of medicine and breast medical oncology at the center, said in a written statement. Therefore, if the approaches used at MD Anderson are applied in the community, similar outcomes can be achieved, he said during a press briefing sponsored by the American Society of Clinical Oncology.

Dr. Buzdar and his colleagues reviewed the center’s detailed database on breast cancer patients dating back to the 1940s. The database included approximately 57,000 breast cancer patients seen between 1944 and 2004. The review included 12,809 patients who had their diagnoses established and treatments initiated at MD Anderson.

Ten-year survival rates improved significantly from the 1944-1954 period to the 1995-2004 period: For local breast cancer, the rates rose from 55% to 86% and for regional breast cancer they increased from 16% to 76%. The survival rate for metastatic disease improved from 3% to 22%.

Disclosures: Dr. Buzdar said he had no financial conflicts to disclose.

Copyright (c) 2010 Elsevier Global Medical News. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.

一个机构在过去60年间所收集的数据资料表明，近几年乳腺癌患者中，有3/4的女性10年后还能存活，而在上个世纪40年代仅有1/4的患者10年后能存活。

 

整体而言，在这60年间，所有类型乳腺癌的10年存活率都显著提高：从1944~1954年间的25％，到1995~2004年间的77%。该项研究的主要负责人在9月29日的报告中称，这一提高主要得益于癌症的早期检测及不同发病期的多种治疗和管理策略的进步。

 

这项研究的主要目标是对休斯顿M.D.安德森癌症中心(MD Anderson Cancer Center in Houston)在过去60年间所收治的乳腺癌患者存活率的逐步改善进行量化评定。研究者表示，如果多模式治疗方案和新的治疗策略可以被快速采纳的话，他们相信，在M.D.安德森癌症中心所观察到的这一存活率能代表小范围内医院和社区癌症中心的存活率情况。

 

该癌症中心临床医学和乳腺癌教授在一份书面报告中称，如果病人能得到适当管理，他们将比过去30年、20年甚至10年时的患者有着更高的乳腺癌存活率，因为治疗手段在不断进步和改善。在由美国临床肿瘤学会(American Society of Clinical Oncology)资助的一次新闻发布会上，研究者称，如果他们在M.D.安德森癌症中心中采用的诊疗手段能够被其他社区医院所采用，其他地方也能取得同样的成功。

 

研究者们回顾了该中心从上个世纪40年代开始乳腺癌患者的详细数据库。该数据库包括大约57,000名1944~2004年之间就诊的乳腺癌患者。回顾的内容包括12,809名起初在M.D.安德森癌症中心就诊和治疗的患者情况。从1944~1954年间到1995~2004年间，乳腺癌的10年存活率显著提高：对于局部乳腺癌，这一存活率从55%提高到86%；对于区域性乳腺癌，这一存活率则由16%提高到76%；而转移性乳腺癌的10年存活率由3%提高到22%。

 

研究者表示无利益冲突需要披露。

 

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