SAN ANTONIO (EGMN) – Colorectal adenomas were significantly more common in adults with type 2 diabetes, compared with the general adult population, based on a study of 860 patients who underwent screening colonoscopy.

“Colonic adenomas and advanced adenomas were independently predicted by diabetes,” wrote Dr. Nisheet Waghray of MetroHealth Medical Center in Cleveland, and colleagues. They presented their findings in a poster Oct. 18 at the annual meeting of the American College of Gastroenterology.

Previous studies have shown a 30%-40% increase in colorectal cancer risk in adults with type 2 diabetes, but the association between type 2 diabetes and the risk of colorectal adenomas has not been well studied, the investigators said.

The researchers reviewed colonoscopy data from 269 adults with type 2 diabetes and 591 adults without diabetes who were screened at a single medical center between January 2007 and January 2010.

All of the following findings – three or more adenomas, adenomas larger than 1 cm, a proximal location of advanced adenomas, and a higher mean number of polyps – were significantly more common in the diabetes patients than in the nondiabetics.

The percentage of patients with three or more adenomas was 14% in those with diabetes vs. 10% in the general population, and the rate of adenomas larger than 1 cm was 9.7% and 4.7%, respectively. The average number of polyps in patients with diabetes vs. those without diabetes was 4.9 vs. 2.5. In addition, 68% of advanced adenomas in the diabetes patients were proximal, compared with 31% of those in the general population.

The average age of the patients with diabetes was 57 years, vs. 61 years in the general population, but this difference was not significant. There were no significant differences between the two groups in terms of body mass index, family history of colorectal cancer, or patient use of alcohol, tobacco, or nonsteroidal anti-inflammatory drugs. Approximately 60% of the patients in both groups were black.

The findings suggest that type 2 diabetes influences not only the number of adenomatous polyps, but also their location within the colon. More research is needed to confirm the results, but this study “adds plausibility that diabetes may play a role in the adenoma-carcinoma sequence,” Dr. Waghray and colleagues noted.

The researchers said that they had no financial conflicts to disclose.

Copyright (c) 2010 Elsevier Global Medical News. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.

圣安东尼奥(EGMN)——美国克利夫兰MetroHealth医疗中心的Nisheet Waghray博士及其同事10月18日在美国胃肠病学会年会壁报展示中称，成人2型糖尿病患者与普通人群相比，罹患结直肠腺瘤的风险显著提高。

 

既往研究发现，成人2型糖尿病患者结直肠癌风险提高30%~-40%，但2型糖尿病与结直肠腺瘤风险的关系却未见深入研究。

 

为此，研究者对2007年1月~2010年1月期间接受结肠镜筛查的269例成人2型糖尿病患者和591例成人非糖尿病患者的资料进行分析。两组患者的年龄、体重指数、结直肠癌家族史以及饮酒、吸烟或非甾体抗炎药物使用情况均无显著差异，均有60%的患者为黑色人种。

 

结果发现， 糖尿病患者和普通人群发生3个或以上腺瘤的比例分别为14%和10%，大于1 cm腺瘤的比例分别为9.7%和4.7%，息肉平均数量分别为4.9个和2.5个，近端结肠晚期腺瘤的比例分别为68%和31%。

 

结果表明，2型糖尿病不仅对腺瘤息肉数量而且对其在结肠内的位置均有影响，提示2型糖尿病与结直肠腺瘤-腺癌高风险具有相关性。

 

研究者声明无经济利益冲突。

 

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