Nbeal2缺陷小鼠中灰色血小板综合症和缺陷血栓-炎症
Introduction
Platelet activation and aggregation at sites of vessel wall injury are crucial to prevent posttraumatic blood loss but may also be major participants in diseases such as myocardial infarction and stroke (1, 2). Inhibition of platelet function is an important strategy for prevention and treatment of ischemic diseases (3). Platelet activation results in shape change, functional upregulation of integrin receptors, and the release from dense granules (δ-granules) and α-granules whose contents amplify the activation response and promote thrombus formation and stability. While δ-granules contain small, nonprotein molecules, such as calcium, serotonin, ADP, and ATP, that promote
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来源: J Clin Invest.
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