近期引入的肝细胞癌筛选生物标记物：系统综述和meta分析

Recently introduced biomarkers for screening of hepatocellular carcinoma: a systematic review and meta-analysis

2013-03-28 15:37点击：224次发表评论

作者：Caroline D. M. Witjes

期刊： 《HEPATOL INT》2013年3月1期7卷

Abstract

Purpose

Early detection of hepatocellular carcinoma (HCC) is essential for improved prognosis and long-term survival. To date, screening for HCC depends on serological testing (alpha-fetoprotein, AFP) and imaging (ultrasonography), both of which are not highly sensitive. A meta-analysis was performed to discuss recent developments in biomarkers that may be effective in screening for HCC.

Methods

A systematic search of PubMed, Embase, and Web of Science was performed for articles published between January 2005 and October 2010, and focusing on biomarkers for HCC in urine, serum, or saliva. Data on sensitivity and specificity of te