中国作者重要发表 - 载脂蛋白E(APOE)基因多态性与白种妇女自然绝经年龄有关



载脂蛋白E(APOE)基因多态性与白种妇女自然绝经年龄有关





A polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian females





He L.-N., Recker R.R., Deng H.-W., Dvornyk V. 2009/5/29 18:39:42

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Maturitas, 2009, Volume 62, Issue 1




Objective: The present study aimed to investigate possible association of the apolipoprotein E (APOE) gene polymorphisms with age at natural menopause (ANM) in Caucasian females. Design: Four SNPs (including two replacements, SNP3 Cys112Arg and SNP4 Arg158Cys) were genotyped in 253 randomly selected unrelated Caucasian women having experienced natural menopause. The comprehensive statistical analyses focusing on the association of the APOE gene and some environmental factors with ANM were conducted. Results: Alcohol consumption was a significantly predictor of earlier natural menopause (P < 0.05). One SNP (rs769450) was significantly associated with ANM according to both population based and the transmission disequilibrium test (TDT) analyses (P = 0.007 and 0.046, respectively). However, no association was observed between APOE ε2, ε3, ε4 and ANM. Conclusions: Genetic variation in the APOE gene may influence the variation in ANM in Caucasian women. © 2008 Elsevier Ireland Ltd. All rights reserved.



Correspondence Address: Dvornyk, V.; School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, Hong Kong; email: dvornyk@hku.hk



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