狼疮性肾炎的筛查、治疗与管理指南

In the US, approximately 35% of adults with systemic lupus erythematosus (SLE) have clinical evidence of nephritis at the time of diagnosis, with an estimated total of 50–60% developing nephritis during the first 10 years of disease (1–4). The prevalence of nephritis is significantly higher in African Americans and Hispanics than in whites, and is higher in men than in women. Renal damage is more likely to develop in nonwhite groups (1–4). Overall survival in patients with SLE is approximately 95% at 5 years after diagnosis and 92% at 10 years after diagnosis (5,6). The presence of lupus nephritis (LN) significantly reduces survival to approximately 88% at 10 years, with even lower survival in African Americans (5,6).