先天性矫正性大动脉转位:系统性房室瓣置换时的心室功能可预测长期心室功能
Objectives:
The objective was to evaluate the systemic ventricular ejection fraction (SVEF) at the time of systemic atrioventricular valve (SAVV) replacement as a predictor of SVEF ≥1year after surgery in patients with congenitally corrected transposition of the great arteries (CCTGA).
Background:
Progressive SAVV regurgitation causes systemic ventricular failure in CCTGA patients, who are commonly referred late for intervention. Survival after surgery is poor when the pre-operative SVEF is <44%.
Methods:
We retrospectively reviewed 46 patients (pre-operative SVEF ≥40% in 27 patients and <40% in 19 patients) with 2 good-sized ventricles, a morphologically right systemic ventricle, and SAVV regurgitation requiring surgery. Median follow-up was not different in patients with a pre-operative SVEF ≥40% (8.8years) or <40% (7.7years, p=0.36).
Results:
Pre-operative SVEF was the only independent predictor of ≥1-year post-operative SVEF (p<0.0001). The late SVEF was preserved (defined as ≥40%) in 63% of patients who underwent surgery with an SVEF <40% compared with 10.5% of patients who underwent surgery with an SVEF <40%. Pre-operative variables associated with late mortality were an SVEF ≤40%, a subpulmonary ventricular systolic pressure ≥50mmHg, atrial fibrillation, and New York Heart Association functional class III to IV.
Conclusions:
Post-operative systemic ventricular function after SAVV replacement can be predicted from the pre-operative SVEF. For best results, operation should be considered at an earlier stage, before the SVEF falls below 40% and the subpulmonary ventricular systolic pressure rises above 50mmHg.
来源: 国际医学期刊
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