多层螺旋CT检查可手术切除的食管胃交界处腺癌的肿瘤体积：相关区域淋巴结转移和N分期

Materials and Methods: The study was approved by the institutional ethics committee, and written informed consent was obtained from each participant. Two hundred sixteen patients with resectable AEG prospectively underwent contrast material-enhanced thoracoabdominal multidetector CT less than 2 weeks before curative resection. Gross tumor volume was retrospectively measured on CT scans. Univariate and multivariate analyses were performed to identify whether gross tumor volume is associated with regional lymph node metastasis. The Mann-Whitney U test was performed to compare gross tumor volume among N stages, with Bonferroni correction for multigroup comparisons. Receiver operating characteristic analysis was performed to determine if gross tumor volume could help classify N stage.

Results: Univariate analysis showed that gross tumor volume is associated with regional lymph node metastasis (P < .0001). Multivariate analysis revealed that gross tumor volume is an independent risk factor of lymph node metastasis (P = .023, odds ratio = 2.791). The Mann-Whitney U test showed that gross tumor volume could help differentiate between stage N0 and stages N1-N2 or N1-N3 disease and between stages N1-N2 and stage N3 disease (P < .0001 for all). In patients with stage T1-T3 AEG, gross tumor volume could help differentiate between stage N0 and stages N1-N2 (cutoff, 15.23 cm3) or N1-N3 (cutoff, 17.16 cm3) disease and between stages N1-N2 and stage N3 disease (cutoff, 33.96 cm3). In patients with stage T3 AEG, gross tumor volume could help differentiate stage N0 from stages N1-N2 (cutoff, 18.41 cm3) or N1-N3 (cutoff, 19.30 cm3) disease and stages N1-N2 from stage N3 disease (cutoff, 33.96 cm3).

Conclusion: Gross tumor volume of AEG measured with multidetector CT is associated with regional lymph node metastasis and N stage. © RSNA, 2013.

学科代码：放射学　　　关键词：adenocarcinoma of the esophago
来源： Scopus