类风湿性关节患者Sjögren综合征的特点

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China

Objective: To compare features of SS in RA with primary SS and RA without SS. Methods: Patients hospitalized between January 2007 and December 2010 were retrospectively studied. Seventy four cases of overlap RA and SS (RA/SS) among 509 cases of RA were identified. Cases of SS (n = 187) detected during the same period acted as controls. Results: Among those with RA/SS, there were 46 cases of RA onset SS and 12 cases of SS onset RA. Sixteen patients had simultaneous onset RA and SS. Compared with RA without SS, RA/SS patients had more severe arthritis; a higher incidence of haematological abnormality, fever and rash; and a higher frequency of RF, ANAs and anti SSA and anti SSB antibodies (P<0.05). Compared with primary SS, RA/SS patients were older, had more severe arthritis, anaemia and lung involvement; a lower incidence of fever, rash, leucopenia, thrombocytopenia and hyperthyroidism; and a higher frequency of RF, anti keratin antibody, anti perinuclear factor and anti cyclic citrullinated antibodies (P<0.05). Compared with RA and primary SS, RA/SS patients had higher disease activity scores of both RA and SS. Conclusion: RA/SS patients have distinctive features, with more complications and systemic involvement. In addition, disease activity is higher in RA/SS. © The Author 2013. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved

Li, Z.; Department of Rheumatology and Immunology, Peking University People's Hospital, 11 Xizhimen South Street, Beijing 100044, China; email:zgli@yahoo.cn