猪鞭虫卵：测试一个以蠕虫为基础的治疗作为卫生假说的扩展

Article Outline

• Abstract
• The hygiene hypothesis
  • Epidemiologic evidence from the developing world (observational studies) supporting the hygiene hypothesis
  • Evidence in support of the hygiene hypothesis from therapeutic interventions in the developing world
  • Evidence in support of the hygiene hypothesis from animal studies
• Trichuris suis
  • Biology of T suis
  • Evidence of the safety of TSO
  • Evidence of the efficacy of TSO
    • IBDs
    • MS
    • Allergic rhinitis
    • Case study in autism
    • Peanut/tree nut allergy
  • Helminths other than T suis
    • N americanus (hookworm)
    • Trichuris trichiura
• Mechanisms responsible for the protective role of helminths
  • ES-62
  • H polygyrus products
  • T suis products
• What now?
  • In terms of clinical trials
  • In terms of basic resea
  
  

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  学科代码：内科学　　　关键词：Hygiene hypothesis helminth Trichuris suis peanut and tree nut allergy mucosal immunity immunomodulation ES-62 clinical trial
  来源： J ALLERGY CLIN IMMUN
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