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Commentaries on selected articles in this issue

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  Maintenance rituximab revisited: is it worth the cost?
Sonali M. Smith
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2331–2332.
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  Advancing therapeutics in human immunodeficiency virus-associated lymphoma: where to go from here?
Kieron Dunleavy
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2333–2334.
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  Total ambulatory hemato-oncological care: a myth or reality?
Chezi Ganzel, Jacob M. Rowe
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2335–2336.
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  Activation of hypoxia signaling is marker of poor prognosis in myelodysplasia
Harold Elias, Amit Verma
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2337–2338.
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  The BRAF-V600E mutation in hematological malignancies: a new player in hairy cell leukemia and Langerhans cell histiocytosis
Tamar Tadmor, Enrico Tiacci, Brunangelo Falini, Aaron Polliack
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2339–2340.
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Reviews

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Diagnosis and management of rare gastrointestinal lymphomas
Eliza A. Hawkes, Andrew Wotherspoon, David Cunningham
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2341–2350.
Summary | Full Text | PDF (356 KB) | PDF Plus (357 KB) | Supplemental Material 

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Off-target effects of BCR–ABL1 inhibitors and their potential long-term implications in patients with chronic myeloid leukemia
Juan Luis Steegmann, Francisco Cervantes, Philipp le Coutre, Kimmo Porkka, Giuseppe Saglio
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2351–2361.
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Targeting the B cell receptor pathway in chronic lymphocytic leukemia
Matthew S. Davids, Jennifer R. Brown
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2362–2370.
Summary | Full Text | PDF (243 KB) | PDF Plus (244 KB) | Supplemental Material 

Original Articles: Clinical

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Cost-effectiveness of rituximab as maintenance therapy in patients with follicular non-Hodgkin lymphoma after responding to first-line rituximab plus chemotherapy
John Hornberger, Rebecca Chien, Mark Friedmann, Leona Han, Ashwini Shewade, Sacha Satram-Hoang, Carolina Reyes
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2371–2377.
Summary | Full Text | PDF (342 KB) | PDF Plus (343 KB) | Supplemental Material 

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Prognosis in primary effusion lymphoma is associated with the number of body cavities involved
Jorge J. Castillo, Helen Shum, Majid Lahijani, Eric S. Winer, James N. Butera
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2378–2382.
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Outcome of patients with relapsed/refractory acquired immune deficiency syndrome-related lymphoma diagnosed 1999–2008 and treated with curative intent in the AIDS Malignancy Consortium
Ulas D. Bayraktar, Juan Carlos Ramos, Adam Petrich, Neel Gupta, Shelly Lensing, P. C. Moore, Erin G. Reid, David M. Aboulafia, Lee Ratner, Ronald Mitsuyasu, Timothy Cooley, David H. Henry, Paul Barr, Ariela Noy
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2383–2389.
Summary | Full Text | PDF (209 KB) | PDF Plus (209 KB) | Supplemental Material 

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Incidence, predictors and significance of severe toxicity in patients with human immunodeficiency virus-associated Hodgkin lymphoma
Hatoon M. Ezzat, Matthew C. Cheung, Lisa K. Hicks, Jordana Boro, Julio S. G. Montaner,Viviane Dias Lima, Marianne Harris, Heather A. Leitch
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2390–2396.
Summary | Full Text | PDF (187 KB) | PDF Plus (187 KB) | Supplemental Material 

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Hotel-based ambulatory care for complex cancer patients: a review of the University College London Hospital experience
Jonathan Sive, Kirit M. Ardeshna, Simon Cheesman, Franel le Grange, Stephen Morris, Claire Nicholas, Karl Peggs, Paula Statham, Anthony H. Goldstone
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2397–2404.
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Neuroleukemiosis: an unusual cause of peripheral neuropathy
Chandan G. Reddy, Michelle L. Mauermann, Benjamin M. Solomon, Michael D. Ringler,Nivedita U. Jerath, Kebede H. Begna, Kimberly K. Amrami, Robert J. Spinner
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2405–2411.
Summary | Full Text | PDF (334 KB) | PDF Plus (335 KB) | Supplemental Material 

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Hypoxia-inducible factor-1α expression indicates poor prognosis in myelodysplastic syndromes
Hongyan Tong, Chao Hu, Zhengping Zhuang, Lijun Wang, Jie Jin
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2412–2418.
Summary | Full Text | PDF (329 KB) | PDF Plus (330 KB) | Supplemental Material 

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Childhood leukemia and its impact on graduation and having children: results from a national survey
Anne Zynda, Simone Reinmuth, Constanze Pfitzer, Cynthia Hohmann, Thomas Keil, Anja Borgmann-Staudt
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2419–2422.
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Potential application of IDH1 and IDH2 mutations as prognostic indicators in non-promyelocytic acute myeloid leukemia: a meta-analysis
Kuang-Guo Zhou, Li-Jun Jiang, Zhen Shang, Jue Wang, Liang Huang, Jian-Feng Zhou
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2423–2429.
Summary | Full Text | PDF (460 KB) | PDF Plus (461 KB) | Supplemental Material 

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Chronic myeloid leukemia in children and adolescents: results of treatment with imatinib mesylate
K. C. Lakshmaiah, Rohan Bhise, Samit Purohit, Linu J. Abraham, D. Lokanatha, T. M. Suresh,L. Appaji, B. S. Arunakumari, K. Govindbabu
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2430–2433.
Summary | Full Text | PDF (180 KB) | PDF Plus (181 KB) | Supplemental Material 

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New recurrent chromosome change in pediatric therapy-related myelodysplastic syndrome: unbalanced translocation 1/6 with cryptic duplication of short arm of chromosome 6
Elisa Tassano, Elisa Tavella, Roberto Valli, Concetta Micalizzi, Cristina Cuoco, Emanuela Maserati, Francesco Pasquali, Cristina Morerio
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2434–2438.
Summary | Full Text | PDF (342 KB) | PDF Plus (343 KB) | Supplemental Material 

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Prognostic features of patients with myelodysplastic syndromes aged < 50 years: update of a single-institution experience
Massimo Breccia, Paola Finsinger, Giuseppina Loglisci, Michelina Santopietro, Adriano Salaroli, Alessandra Serrao, Roberto Latagliata, Paola Volpicelli, Luigi Petrucci, Mauro Nanni,Giuliana Alimena
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2439–2443.
Summary | Full Text | PDF (162 KB) | PDF Plus (163 KB) | Supplemental Material 

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Association of age with fluorescence in situ hybridization abnormalities in multiple myeloma reveals higher rate of IGH translocations among older patients
Charles Butler, Daynna J. Wolff, Yubin Kang, Robert K. Stuart, Luciano J. Costa
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2444–2448.
Summary | Full Text | PDF (307 KB) | PDF Plus (308 KB) | Supplemental Material 

Original Articles: Research

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Recurrent breakpoints in 14q32.13/TCL1A region in mature B-cell neoplasms with villous lymphocytes
Helena Urbankova, Mathijs Baens, Lucienne Michaux, Thomas Tousseyn, Katrina Rack, Beata Katrincsakova, Julio Finalet Ferreiro, Peter van Loo, Wim de Kelver, Daan Dierickx, Hilde Demuynck, André Delannoy, Johan Verschuere, Marie Jarošová, Chris de Wolf-Peeters, Peter Vandenberghe, Iwona Wlodarska
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2449–2455.
Summary | Full Text | PDF (496 KB) | PDF Plus (497 KB) | Supplemental Material 

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Novel function of scutellarin in inhibiting cell proliferation and inducing cell apoptosis of human Burkitt lymphoma Namalwa cells
Yizhong Feng, Shasha Zhang, Jian Tu, Zhifei Cao, Yanyan Pan, Bingxue Shang, Ruifang Liu,Meimei Bao, Pengda Guo, Quansheng Zhou
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2456–2464.
Summary | Full Text | PDF (483 KB) | PDF Plus (484 KB) | Supplemental Material 

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Aberrant microRNA-182 expression is associated with glucocorticoid resistance in lymphoblastic malignancies
Apeng Yang, Jiexian Ma, Min Wu, Wenming Qin, Botao Zhao, Yi Shi, Youxin Jin, Yanhui Xie
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2465–2473.
Summary | Full Text | PDF (480 KB) | PDF Plus (481 KB) | Supplemental Material 

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Chronic myeloid leukemia stem cells display alterations in expression of genes involved in oxidative phosphorylation
Krzysztof Flis, David Irvine, Mhairi Copland, Ravi Bhatia, Tomasz Skorski
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2474–2478.
Summary | Full Text | PDF (767 KB) | PDF Plus (768 KB) | Supplemental Material 

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Detection of JAK2 mutations in paraffin marrow biopsies by high resolution melting analysis: identification of L611S alone and in cis with V617F in polycythemia vera
Roberto H. Nussenzveig, Tatiana Burjanivova, Mohamed E. Salama, Natalie W. Ogilvie, Juraj Marcinek, Lukas Plank, Archana M. Agarwal, Sherrie L. Perkins, Josef T. Prchal
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2479–2486.
Summary | Full Text | PDF (439 KB) | PDF Plus (440 KB) | Supplemental Material 

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Synergistic/additive interaction of valproic acid with bortezomib on proliferation and apoptosis of acute myeloid leukemia cells
Danian Nie, Kezhi Huang, Songmei Yin, Yiqing Li, Shuangfeng Xie, Liping Ma, Xiuju Wang,Yudan Wu, Jie Xiao
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2487–2495.
Summary | Full Text | PDF (509 KB) | PDF Plus (510 KB) | Supplemental Material 

Letters to the Editor

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Absence of BRAF V600E mutation in a cohort of 402 patients with various chronic and acute myeloid neoplasms
Adrian P. Trifa, Radu A. Popp, Andrei Cucuianu, Camelia A. Coadă, Laura G. Urian, Mariela S. Militaru, Claudia Bănescu, Delia Dima, Marius F. Farcaş, Tania O. Crişan, Ljubomir Petrov,Cristina Gug, Ioan V. Pop
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2496–2497.
Citation | Full Text | PDF (147 KB) | PDF Plus (148 KB) | Supplemental Material 

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Absence of BRAF V600E mutation in hematologic malignancies excluding hairy-cell leukemia
Nana Ping, Qinrong Wang, Qian Wang, Shasha Dong, Lili Wu, Yongquan Xue, Changgeng Ruan, Depei Wu, Suning Chen
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2498–2499.
Citation | Full Text | PDF (149 KB) | PDF Plus (150 KB) | Supplemental Material 

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1q21 amplification with additional genetic abnormalities but not isolated 1q21 gain is a negative prognostic factor in newly diagnosed patients with multiple myeloma treated with thalidomide-based regimens
Norbert Grzasko, Marek Hus, Sylwia Chocholska, Andrzej Pluta, Roman Hajek, Anna Dmoszynska
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2500–2503.
Citation | Full Text | PDF (251 KB) | PDF Plus (252 KB) | Supplemental Material 

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Epstein–Barr virus-associated B-cell lymphoma of the spleen resembling infectious mononucleosis morphologically
Masaru Kojima, Masahiro Noro, Yoshimasa Nakazato, Bunshiro Akikusa, Jun-ichi Tamaru,Nobuhide Masawa, Makoto Kashimura
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2504–2506.
Citation | Full Text | PDF (325 KB) | PDF Plus (326 KB) | Supplemental Material 

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High-dose melphalan with bortezomib as conditioning regimen for autologous stem cell transplant in patients with newly diagnosed multiple myeloma who exhibited at least very good partial response to bortezomib-based induction therapy
Wenrong Huang, Jian Li, Honghua Li, Wenying Kang, Jian Bo, Yu Zhao, Chunji Gao, Daobin Zhou, Li Yu
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2507–2510.
Citation | Full Text | PDF (172 KB) | PDF Plus (173 KB) | Supplemental Material 

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Myeloid sarcoma of the heart
Raya Mawad, David Wu, Janis L. Abkowitz, Roland B. Walter
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2511–2514.
Citation | Full Text | PDF (738 KB) | PDF Plus (738 KB) | Supplemental Material 

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Panhypopituitarism and diabetes insipidus in a patient with primary central nervous system lymphoma
Olivier Malaise, Nicolas Frusch, Emmanuel Beck, Sophie Servais, Jo Caers, Jo Caers,Bernard de Prijck, Daniela Betea, Yves Beguin
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2515–2516.
Citation | Full Text | PDF (148 KB) | PDF Plus (148 KB) | Supplemental Material 

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MicroRNA profiling in pediatric acute lymphoblastic leukemia: novel prognostic tools
Neda Mosakhani, Virinder Kaur Sarhadi, Anu Usvasalo, Marja-Liisa Karjalainen-Lindsberg,Leo Lahti, Katja Tuononen, Ulla M. Saarinen-Pihkala, Sakari Knuutila
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2517–2520.
Citation | Full Text | PDF (284 KB) | PDF Plus (285 KB) | Supplemental Material 

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A hemodialysis patient with higher-risk myelodysplastic syndrome treated with standard-dose azacitidine
Johanna C. Ham, Judith M. Hoogendijk-van den Akker, Leo F. Verdonck
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2521–2522.
Citation | Full Text | PDF (128 KB) | PDF Plus (129 KB) | Supplemental Material 

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Negative impact of FLT3-ITD mutation on expression of MDR-1 mRNA in adult acute myeloid leukemia
Barbara Nasiłowska-Adamska, Iwona Solarska
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2523–2526.
Citation | Full Text | PDF (210 KB) | PDF Plus (211 KB) | Supplemental Material 

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Bortezomib and dexamethasone as first-line therapy for a patient with newly diagnosed polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes syndrome complicated by renal failure
Jian Li, Wei Zhang, Wen-Ying Kang, Xin-Xin Cao, Ming-Hui Duan, Dao-Bin Zhou
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2527–2529.
Citation | Full Text | PDF (183 KB) | PDF Plus (184 KB) | Supplemental Material 

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First case of donor transmitted non-leukemic promyelocytic sarcoma
Travis Williams, Omar S. Aljitawi, Ronnie Moussa, Sarah McHugh, Reginald Dusing, Joseph Abraha, Sri G. Yarlagadda
Leukemia & Lymphoma Dec 2012, Vol. 53, No. 12: 2530–2534.
Citation | Full Text | PDF (366 KB) | PDF Plus (367 KB) | Supplemental Material 



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