啮齿类模型中衰老过程循环和静脉壁P选择素可促进静脉血栓形成

Circulating and vein wall P-selectin promote venous thrombogenesis during aging in a rodent model
作者:Dorian Laird Culmer,
期刊: THROMB RES2013年1月1期131卷

 

Article Outline

  • Abstract
  • Introduction
  • Materials and Methods
    • Mice
    • Animal model
    • Thrombus Weight (TW)
    • Plasma Soluble P-selectin (sP) and Soluble E-selectin (sE)
    • Vein Wall Protein Analysis P- and E-selectin
    • Quantitative (real time) Polymerase Chain Reaction (qRT-PCR)
    • Vein Wall Morphometrics
    • Hematology
    • Statistical Analysis and Animal Use
  • Results
    • Aging Promotes Venous Thrombosis
    • Soluble P-selectin is Higher in Older Mice
    • Soluble E-selectin is Lower in Older Mice
    • Vein Wall P-selectin was Increased in Older Mice

    学科代码:内科学   关键词:Venous thrombosis Aging Selectin biology Animal model Inflammation
    来源: Thrombosis Research
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