中国湖南省2015年重症儿童中的重组欧亚禽流感样病毒A(H1N1)病毒

Reassortant eurasian avian-like influenza A(H1N1) virus from a severely Ill child, Hunan Province, China, 2015
2017-03-02 09:30发表评论
作者:Zhu, W, Zhang, H, Xiang, X, Zhong, L.d, Yang, L, Guo, J, Xie, Y, Li, F, Deng, Z, Feng, H.e, Huang, Y, Hu, S, Xu, X.e, Zou, X, Li, X, Bai, T, Chen, Y, Li, Z, Li, J , Shu, Y
机构: 中国疾病预防控制中心,国家病毒疾病控制与预防研究所
期刊: EMERG INFECT DIS2016年11月11期22卷

In 2015, a novel influenza A(H1N1) virus was isolated from a boy in China who had severe pneumonia. The virus was a genetic reassortant of Eurasian avian-like influenza A(H1N1) (EA-H1N1) virus. The hemagglutinin, neuraminidase, and matrix genes of the reassortant virus were highly similar to genes in EA-H1N1 swine influenza viruses, the polybasic 1 and 2, polymerase acidic, and nucleoprotein genes originated from influenza A(H1N1)pdm09 virus, and the nonstructural protein gene derived from classical swine influenza A(H1N1) (CS H1N1) virus. In a mouse model, the reassortant virus, termed influenza A/Hunan/42443/2015(H1N1) virus, showed higher infectivity and virulence than another human EA-H1N1 isolate, influenza A/Jiangsu/1/2011(H1N1) virus. In the respiratory tract of mice, virus replication by influenza A/Hunan/42443/2015(H1N1) virus was substantially higher than that by influenza A/Jiangsu/1/2011(H1N1) virus. Human-to-human transmission of influenza A/Hunan/42443/2015(H1N1) virus has not been detected; however, given the circulation of novel EA-H1N1 viruses in pigs, enhanced surveillance should be instituted among swine and humans. © 2016, Emerging Infectious Diseases. All rights reserved.

通讯机构:National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
学科代码:感染病学   关键词:重症儿童 禽流感样病毒A(H1N1)病毒 ,中国作者重要发表 爱思唯尔医学网, Elseviermed
来源: Scopus
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